Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome

Human embryonic stem cells (hESCs) readily differentiate to somatic or germ lineages but have impaired ability to form extra-embryonic lineages such as placenta or yolk sac. Here, we demonstrate that naive hESCs can be converted into cells that exhibit the cellular and molecular phenotypes of human...

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Detalles Bibliográficos
Autores principales: Cinkornpumin, Jessica K., Kwon, Sin Young, Guo, Yixin, Hossain, Ishtiaque, Sirois, Jacinthe, Russett, Colleen S., Tseng, Hsin-Wei, Okae, Hiroaki, Arima, Takahiro, Duchaine, Thomas F., Liu, Wanlu, Pastor, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363941/
https://www.ncbi.nlm.nih.gov/pubmed/32619492
http://dx.doi.org/10.1016/j.stemcr.2020.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363941/
https://www.ncbi.nlm.nih.gov/pubmed/32619492
http://dx.doi.org/10.1016/j.stemcr.2020.06.003

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