Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

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The hippocampus is important for memory formation and is severely affected in the brain with Alzheimer disease (AD). Our understanding of early pathogenic processes occurring in hippocampi in AD is limited due to tissue unavailability. Here, we report a chemical approach to rapidly generate free-flo...

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Detalles Bibliográficos
Autores principales: Pomeshchik, Yuriy, Klementieva, Oxana, Gil, Jeovanis, Martinsson, Isak, Hansen, Marita Grønning, de Vries, Tessa, Sancho-Balsells, Anna, Russ, Kaspar, Savchenko, Ekaterina, Collin, Anna, Vaz, Ana Rita, Bagnoli, Silvia, Nacmias, Benedetta, Rampon, Claire, Sorbi, Sandro, Brites, Dora, Marko-Varga, György, Kokaia, Zaal, Rezeli, Melinda, Gouras, Gunnar K., Roybon, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363942/
https://www.ncbi.nlm.nih.gov/pubmed/32589876
http://dx.doi.org/10.1016/j.stemcr.2020.06.001
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