Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series

Two patients with normal renal function, yet each showed unexpected, supra‐ and subtherapeutic linezolid plasma concentrations resulting in toxicity and ineffective therapy, respectively. TDM helps to early identify and correct such excursions.

Detalles Bibliográficos
Autores principales: Alghamdi, Wael A., Al‐Shaer, Mohammad H., Klinker, Kenneth P., Peloquin, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364108/
https://www.ncbi.nlm.nih.gov/pubmed/32695341
http://dx.doi.org/10.1002/ccr3.2835
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author Alghamdi, Wael A.
Al‐Shaer, Mohammad H.
Klinker, Kenneth P.
Peloquin, Charles A.
author_facet Alghamdi, Wael A.
Al‐Shaer, Mohammad H.
Klinker, Kenneth P.
Peloquin, Charles A.
author_sort Alghamdi, Wael A.
collection PubMed
description Two patients with normal renal function, yet each showed unexpected, supra‐ and subtherapeutic linezolid plasma concentrations resulting in toxicity and ineffective therapy, respectively. TDM helps to early identify and correct such excursions.
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spelling pubmed-73641082020-07-20 Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series Alghamdi, Wael A. Al‐Shaer, Mohammad H. Klinker, Kenneth P. Peloquin, Charles A. Clin Case Rep Case Reports Two patients with normal renal function, yet each showed unexpected, supra‐ and subtherapeutic linezolid plasma concentrations resulting in toxicity and ineffective therapy, respectively. TDM helps to early identify and correct such excursions. John Wiley and Sons Inc. 2020-04-13 /pmc/articles/PMC7364108/ /pubmed/32695341 http://dx.doi.org/10.1002/ccr3.2835 Text en © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Alghamdi, Wael A.
Al‐Shaer, Mohammad H.
Klinker, Kenneth P.
Peloquin, Charles A.
Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series
title Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series
title_full Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series
title_fullStr Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series
title_full_unstemmed Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series
title_short Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series
title_sort variable linezolid exposure and response and the role of therapeutic drug monitoring: case series
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364108/
https://www.ncbi.nlm.nih.gov/pubmed/32695341
http://dx.doi.org/10.1002/ccr3.2835
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