MicroRNA-122 aggravates angiotensin II-mediated apoptosis and autophagy imbalance in rat aortic adventitial fibroblasts via the modulation of SIRT6-elabela-ACE2 signaling

Abnormal aortic adventitial fibroblasts (AFs) play essential roles in the development of vascular remodeling and disorders. Previous studies revealed that microRNA-122 (miR-122) levels were elevated in the aortic adventitia of hypertensive rats with vascular injury. Here, we aim to evaluate the biol...

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Detalles Bibliográficos
Autores principales: Song, Juan-Juan, Yang, Mei, Liu, Ying, Song, Jia-Wei, Wang, Juan, Chi, Hong-Jie, Liu, Xiao-Yan, Zuo, Kun, Yang, Xin-Chun, Zhong, Jiu-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364171/
https://www.ncbi.nlm.nih.gov/pubmed/32682786
http://dx.doi.org/10.1016/j.ejphar.2020.173374

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