Testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier function

Background: Sequestration and cytoadherence of Plasmodium falciparum-infected erythrocytes (IE) to microvascular endothelium alters endothelial barrier function and plays a role in the pathogenesis of severe malaria. Binding of IE is mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1)...

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Detalles Bibliográficos
Autores principales: Storm, Janet, Wu, Yang, Davies, Jill, Moxon, Christopher A., Craig, Alister G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364184/
https://www.ncbi.nlm.nih.gov/pubmed/32724861
http://dx.doi.org/10.12688/wellcomeopenres.15602.3

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