Fulminant Hepatitis due to de novo Hepatitis B after Cord Blood Transplantation Rescued by Medical Treatment

A 53-year-old man presented with fulminant hepatitis due to de novo hepatitis B. He had been diagnosed previously with adult T-cell leukemia (ATL) and previously resolved hepatitis B virus infection. The ATL had been treated with cord blood transplantation (CBT). He developed fulminant hepatitis 18...

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Autores principales: Sano, Tomoya, Akuta, Norio, Suzuki, Yoshiyuki, Kasuya, Kayoko, Fujiyama, Shunichiro, Kawamura, Yusuke, Sezaki, Hitomi, Hosaka, Tetsuya, Saitoh, Satoshi, Kobayashi, Masahiro, Suzuki, Fumitaka, Kobayashi, Mariko, Arase, Yasuji, Ikeda, Kenji, Kumada, Hiromitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364250/
https://www.ncbi.nlm.nih.gov/pubmed/32536678
http://dx.doi.org/10.2169/internalmedicine.4190-19
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author Sano, Tomoya
Akuta, Norio
Suzuki, Yoshiyuki
Kasuya, Kayoko
Fujiyama, Shunichiro
Kawamura, Yusuke
Sezaki, Hitomi
Hosaka, Tetsuya
Saitoh, Satoshi
Kobayashi, Masahiro
Suzuki, Fumitaka
Kobayashi, Mariko
Arase, Yasuji
Ikeda, Kenji
Kumada, Hiromitsu
author_facet Sano, Tomoya
Akuta, Norio
Suzuki, Yoshiyuki
Kasuya, Kayoko
Fujiyama, Shunichiro
Kawamura, Yusuke
Sezaki, Hitomi
Hosaka, Tetsuya
Saitoh, Satoshi
Kobayashi, Masahiro
Suzuki, Fumitaka
Kobayashi, Mariko
Arase, Yasuji
Ikeda, Kenji
Kumada, Hiromitsu
author_sort Sano, Tomoya
collection PubMed
description A 53-year-old man presented with fulminant hepatitis due to de novo hepatitis B. He had been diagnosed previously with adult T-cell leukemia (ATL) and previously resolved hepatitis B virus infection. The ATL had been treated with cord blood transplantation (CBT). He developed fulminant hepatitis 18 months after CBT, 15 months after the withdrawal of immunosuppressants, and 10 months after vitreous injections of methotrexate for ATL-related retinal infiltration. The aggressive medical protocol included entecavir, prednisolone, plasma exchange, hemodialysis, and bilirubin adsorption. We herein report successful medical treatment for fulminant de novo hepatitis B in a patient considered unsuitable for liver transplantation.
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spelling pubmed-73642502020-07-30 Fulminant Hepatitis due to de novo Hepatitis B after Cord Blood Transplantation Rescued by Medical Treatment Sano, Tomoya Akuta, Norio Suzuki, Yoshiyuki Kasuya, Kayoko Fujiyama, Shunichiro Kawamura, Yusuke Sezaki, Hitomi Hosaka, Tetsuya Saitoh, Satoshi Kobayashi, Masahiro Suzuki, Fumitaka Kobayashi, Mariko Arase, Yasuji Ikeda, Kenji Kumada, Hiromitsu Intern Med Case Report A 53-year-old man presented with fulminant hepatitis due to de novo hepatitis B. He had been diagnosed previously with adult T-cell leukemia (ATL) and previously resolved hepatitis B virus infection. The ATL had been treated with cord blood transplantation (CBT). He developed fulminant hepatitis 18 months after CBT, 15 months after the withdrawal of immunosuppressants, and 10 months after vitreous injections of methotrexate for ATL-related retinal infiltration. The aggressive medical protocol included entecavir, prednisolone, plasma exchange, hemodialysis, and bilirubin adsorption. We herein report successful medical treatment for fulminant de novo hepatitis B in a patient considered unsuitable for liver transplantation. The Japanese Society of Internal Medicine 2020-06-15 2020-06-15 /pmc/articles/PMC7364250/ /pubmed/32536678 http://dx.doi.org/10.2169/internalmedicine.4190-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sano, Tomoya
Akuta, Norio
Suzuki, Yoshiyuki
Kasuya, Kayoko
Fujiyama, Shunichiro
Kawamura, Yusuke
Sezaki, Hitomi
Hosaka, Tetsuya
Saitoh, Satoshi
Kobayashi, Masahiro
Suzuki, Fumitaka
Kobayashi, Mariko
Arase, Yasuji
Ikeda, Kenji
Kumada, Hiromitsu
Fulminant Hepatitis due to de novo Hepatitis B after Cord Blood Transplantation Rescued by Medical Treatment
title Fulminant Hepatitis due to de novo Hepatitis B after Cord Blood Transplantation Rescued by Medical Treatment
title_full Fulminant Hepatitis due to de novo Hepatitis B after Cord Blood Transplantation Rescued by Medical Treatment
title_fullStr Fulminant Hepatitis due to de novo Hepatitis B after Cord Blood Transplantation Rescued by Medical Treatment
title_full_unstemmed Fulminant Hepatitis due to de novo Hepatitis B after Cord Blood Transplantation Rescued by Medical Treatment
title_short Fulminant Hepatitis due to de novo Hepatitis B after Cord Blood Transplantation Rescued by Medical Treatment
title_sort fulminant hepatitis due to de novo hepatitis b after cord blood transplantation rescued by medical treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364250/
https://www.ncbi.nlm.nih.gov/pubmed/32536678
http://dx.doi.org/10.2169/internalmedicine.4190-19
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