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Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study
RATIONALE: COVID-19 ARDS could differ from typical forms of the syndrome. OBJECTIVE: Pulmonary microvascular injury and thrombosis are increasingly reported as constitutive features of COVID-19 respiratory failure. Our aim was to study pulmonary mechanics and gas exchanges in COVID-2019 ARDS patient...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364286/ https://www.ncbi.nlm.nih.gov/pubmed/32676824 http://dx.doi.org/10.1186/s13613-020-00716-1 |
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author | Diehl, J.-L. Peron, N. Chocron, R. Debuc, B. Guerot, E. Hauw-Berlemont, C. Hermann, B. Augy, J. L. Younan, R. Novara, A. Langlais, J. Khider, L. Gendron, N. Goudot, G. Fagon, J.-F. Mirault, T. Smadja, D. M. |
author_facet | Diehl, J.-L. Peron, N. Chocron, R. Debuc, B. Guerot, E. Hauw-Berlemont, C. Hermann, B. Augy, J. L. Younan, R. Novara, A. Langlais, J. Khider, L. Gendron, N. Goudot, G. Fagon, J.-F. Mirault, T. Smadja, D. M. |
author_sort | Diehl, J.-L. |
collection | PubMed |
description | RATIONALE: COVID-19 ARDS could differ from typical forms of the syndrome. OBJECTIVE: Pulmonary microvascular injury and thrombosis are increasingly reported as constitutive features of COVID-19 respiratory failure. Our aim was to study pulmonary mechanics and gas exchanges in COVID-2019 ARDS patients studied early after initiating protective invasive mechanical ventilation, seeking after corresponding pathophysiological and biological characteristics. METHODS: Between March 22 and March 30, 2020 respiratory mechanics, gas exchanges, circulating endothelial cells (CEC) as markers of endothelial damage, and D-dimers were studied in 22 moderate-to-severe COVID-19 ARDS patients, 1 [1–4] day after intubation (median [IQR]). MEASUREMENTS AND MAIN RESULTS: Thirteen moderate and 9 severe COVID-19 ARDS patients were studied after initiation of high PEEP protective mechanical ventilation. We observed moderately decreased respiratory system compliance: 39.5 [33.1–44.7] mL/cmH(2)O and end-expiratory lung volume: 2100 [1721–2434] mL. Gas exchanges were characterized by hypercapnia 55 [44–62] mmHg, high physiological dead-space (V(D)/V(T)): 75 [69–85.5] % and ventilatory ratio (VR): 2.9 [2.2–3.4]. V(D)/V(T) and VR were significantly correlated: r(2) = 0.24, p = 0.014. No pulmonary embolism was suspected at the time of measurements. CECs and D-dimers were elevated as compared to normal values: 24 [12–46] cells per mL and 1483 [999–2217] ng/mL, respectively. CONCLUSIONS: We observed early in the course of COVID-19 ARDS high V(D)/V(T) in association with biological markers of endothelial damage and thrombosis. High V(D)/V(T) can be explained by high PEEP settings and added instrumental dead space, with a possible associated role of COVID-19-triggered pulmonary microvascular endothelial damage and microthrombotic process. |
format | Online Article Text |
id | pubmed-7364286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-73642862020-07-16 Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study Diehl, J.-L. Peron, N. Chocron, R. Debuc, B. Guerot, E. Hauw-Berlemont, C. Hermann, B. Augy, J. L. Younan, R. Novara, A. Langlais, J. Khider, L. Gendron, N. Goudot, G. Fagon, J.-F. Mirault, T. Smadja, D. M. Ann Intensive Care Research RATIONALE: COVID-19 ARDS could differ from typical forms of the syndrome. OBJECTIVE: Pulmonary microvascular injury and thrombosis are increasingly reported as constitutive features of COVID-19 respiratory failure. Our aim was to study pulmonary mechanics and gas exchanges in COVID-2019 ARDS patients studied early after initiating protective invasive mechanical ventilation, seeking after corresponding pathophysiological and biological characteristics. METHODS: Between March 22 and March 30, 2020 respiratory mechanics, gas exchanges, circulating endothelial cells (CEC) as markers of endothelial damage, and D-dimers were studied in 22 moderate-to-severe COVID-19 ARDS patients, 1 [1–4] day after intubation (median [IQR]). MEASUREMENTS AND MAIN RESULTS: Thirteen moderate and 9 severe COVID-19 ARDS patients were studied after initiation of high PEEP protective mechanical ventilation. We observed moderately decreased respiratory system compliance: 39.5 [33.1–44.7] mL/cmH(2)O and end-expiratory lung volume: 2100 [1721–2434] mL. Gas exchanges were characterized by hypercapnia 55 [44–62] mmHg, high physiological dead-space (V(D)/V(T)): 75 [69–85.5] % and ventilatory ratio (VR): 2.9 [2.2–3.4]. V(D)/V(T) and VR were significantly correlated: r(2) = 0.24, p = 0.014. No pulmonary embolism was suspected at the time of measurements. CECs and D-dimers were elevated as compared to normal values: 24 [12–46] cells per mL and 1483 [999–2217] ng/mL, respectively. CONCLUSIONS: We observed early in the course of COVID-19 ARDS high V(D)/V(T) in association with biological markers of endothelial damage and thrombosis. High V(D)/V(T) can be explained by high PEEP settings and added instrumental dead space, with a possible associated role of COVID-19-triggered pulmonary microvascular endothelial damage and microthrombotic process. Springer International Publishing 2020-07-16 /pmc/articles/PMC7364286/ /pubmed/32676824 http://dx.doi.org/10.1186/s13613-020-00716-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Diehl, J.-L. Peron, N. Chocron, R. Debuc, B. Guerot, E. Hauw-Berlemont, C. Hermann, B. Augy, J. L. Younan, R. Novara, A. Langlais, J. Khider, L. Gendron, N. Goudot, G. Fagon, J.-F. Mirault, T. Smadja, D. M. Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study |
title | Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study |
title_full | Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study |
title_fullStr | Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study |
title_full_unstemmed | Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study |
title_short | Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study |
title_sort | respiratory mechanics and gas exchanges in the early course of covid-19 ards: a hypothesis-generating study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364286/ https://www.ncbi.nlm.nih.gov/pubmed/32676824 http://dx.doi.org/10.1186/s13613-020-00716-1 |
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