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FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism. This is thought to cause the spreading of Tau...

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Detalles Bibliográficos
Autores principales:	Kaniyappan, Senthilvelrajan, Tepper, Katharina, Biernat, Jacek, Chandupatla, Ram Reddy, Hübschmann, Sabrina, Irsen, Stephan, Bicher, Sandra, Klatt, Christoph, Mandelkow, Eva-Maria, Mandelkow, Eckhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364478/ https://www.ncbi.nlm.nih.gov/pubmed/32677995 http://dx.doi.org/10.1186/s13024-020-00389-1

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