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Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients

We enrolled 122 patients with glioma who received surgery treatment in our hospital from June 2010 to May 2012, and 60 healthy individuals. We found that the plasma miR-720 in the glioma group was significantly higher than that in the healthy control group (3.19 ± 1.26 vs 0.98 ± 0.65, P<0.001). T...

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Detalles Bibliográficos
Autores principales: Chen, Peng, Zhang, Guangying, Zhou, Qin, Li, Zhanzhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364510/
https://www.ncbi.nlm.nih.gov/pubmed/32639004
http://dx.doi.org/10.1042/BSR20201449
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author Chen, Peng
Zhang, Guangying
Zhou, Qin
Li, Zhanzhan
author_facet Chen, Peng
Zhang, Guangying
Zhou, Qin
Li, Zhanzhan
author_sort Chen, Peng
collection PubMed
description We enrolled 122 patients with glioma who received surgery treatment in our hospital from June 2010 to May 2012, and 60 healthy individuals. We found that the plasma miR-720 in the glioma group was significantly higher than that in the healthy control group (3.19 ± 1.26 vs 0.98 ± 0.65, P<0.001). The sensitivity and specificity were 71.3% (95%CI: 62.4–79.1%) and 83.3% (71.5–91.7%), respectively. The results indicated that the plasma miR-720 level was associated with tumor grade (t = 104.418, P<0.001). The advanced tumor tended to have higher miR-720 expression level. No significant association was found between miR-720 and age, sex, tumor size, KPS and tumor position (P=0.438, 0.514, 0.518, 0.058, 0.226). The multivariate cox analysis indicated that the high expression of miR-720 (HR = 1.48, 95%CI: 1.12–2.97, P=0.023) was independently predictors of adverse prognosis in patients with glioma. The high expression of miR-720 was also associated with recurrence or development in patients with glioma (HR = 1.47, 95%CI: 1.18–3.14, P=0.012). Plasma miR-720 has a moderate diagnostic ability in early diagnostic of glioma and may be a potential tumor biomarker. The high plasma miR-720 was related to adverse prognosis in patients with glioma and could be a prognosis predictor of glioma patients.
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spelling pubmed-73645102020-07-27 Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients Chen, Peng Zhang, Guangying Zhou, Qin Li, Zhanzhan Biosci Rep Cancer We enrolled 122 patients with glioma who received surgery treatment in our hospital from June 2010 to May 2012, and 60 healthy individuals. We found that the plasma miR-720 in the glioma group was significantly higher than that in the healthy control group (3.19 ± 1.26 vs 0.98 ± 0.65, P<0.001). The sensitivity and specificity were 71.3% (95%CI: 62.4–79.1%) and 83.3% (71.5–91.7%), respectively. The results indicated that the plasma miR-720 level was associated with tumor grade (t = 104.418, P<0.001). The advanced tumor tended to have higher miR-720 expression level. No significant association was found between miR-720 and age, sex, tumor size, KPS and tumor position (P=0.438, 0.514, 0.518, 0.058, 0.226). The multivariate cox analysis indicated that the high expression of miR-720 (HR = 1.48, 95%CI: 1.12–2.97, P=0.023) was independently predictors of adverse prognosis in patients with glioma. The high expression of miR-720 was also associated with recurrence or development in patients with glioma (HR = 1.47, 95%CI: 1.18–3.14, P=0.012). Plasma miR-720 has a moderate diagnostic ability in early diagnostic of glioma and may be a potential tumor biomarker. The high plasma miR-720 was related to adverse prognosis in patients with glioma and could be a prognosis predictor of glioma patients. Portland Press Ltd. 2020-07-15 /pmc/articles/PMC7364510/ /pubmed/32639004 http://dx.doi.org/10.1042/BSR20201449 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Cancer
Chen, Peng
Zhang, Guangying
Zhou, Qin
Li, Zhanzhan
Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients
title Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients
title_full Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients
title_fullStr Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients
title_full_unstemmed Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients
title_short Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients
title_sort plasma microrna-720 may predict prognosis and diagnosis in glioma patients
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364510/
https://www.ncbi.nlm.nih.gov/pubmed/32639004
http://dx.doi.org/10.1042/BSR20201449
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