Cargando…
Development and Validation of a Kilogram-Scale Synthesis of Tirapazamine
[Image: see text] The process selection and subsequent development of a reliable, scalable synthesis of the anticancer prodrug tirapazamine (SR259075) is described in this paper. Reaction of benzofuroxan with cyanamide in acetonitrile in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene at 20–25 °C...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364547/ https://www.ncbi.nlm.nih.gov/pubmed/32685820 http://dx.doi.org/10.1021/acsomega.0c01250 |