In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression

BACKGROUND: The pathogenesis of pulmonary arterial hypertension (PAH) involves many signalling pathways. MicroRNAs are potential candidates involved in simultaneously coordinating multiple genes under such multifactorial conditions. METHODS AND RESULTS: MiR-138-5p is overexpressed in pulmonary arter...

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Detalles Bibliográficos
Autores principales: Le Ribeuz, Hélène, Courboulin, Audrey, Ghigna, Maria-Rosa, Lambert, Mélanie, Hautefort, Aurélie, Humbert, Marc, Montani, David, Cohen-Kaminsky, Sylvia, Perros, Frédéric, Antigny, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364627/
https://www.ncbi.nlm.nih.gov/pubmed/32678044
http://dx.doi.org/10.1186/s12931-020-01444-7

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