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Association between TERT gene polymorphisms and acute myeloid leukemia susceptibility in a Chinese population: a case–control study
BACKGROUND: The aim of this study was to investigate the association between telomerase reverse transcriptase (TERT) gene polymorphisms and acute myeloid leukemia (AML) susceptibility in a Chinese Han population. METHODS: A total of 102 AML patients and 108 healthy controls were enrolled in this cas...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364641/ https://www.ncbi.nlm.nih.gov/pubmed/32694935 http://dx.doi.org/10.1186/s12935-020-01335-3 |
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author | Tong, Yong Xiang, Yinzhou Li, Bao Bao, Shijie Zhou, Ying Yuan, Wen Ling, Yu Hao, Dan Zhu, Huamin Sun, Zhiqiang |
author_facet | Tong, Yong Xiang, Yinzhou Li, Bao Bao, Shijie Zhou, Ying Yuan, Wen Ling, Yu Hao, Dan Zhu, Huamin Sun, Zhiqiang |
author_sort | Tong, Yong |
collection | PubMed |
description | BACKGROUND: The aim of this study was to investigate the association between telomerase reverse transcriptase (TERT) gene polymorphisms and acute myeloid leukemia (AML) susceptibility in a Chinese Han population. METHODS: A total of 102 AML patients and 108 healthy controls were enrolled in this case–control study. TERT gene rs2853669 and rs2736100 polymorphisms were genotyped via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Chi-square test was applied to compare polymorphism distributions between case and control groups. The strength of the association between TERT gene polymorphisms and AML susceptibility was evaluated utilizing odds ratio (OR) with corresponding 95% confidence interval (CI). RESULTS: CC genotype and C allele of rs2736100 polymorphism were more frequent in AML patients (P < 0.05), and individuals carrying CC genotype showed higher risk of suffering from AML (OR = 2.632, 95% CI 1.129–6.133). But for rs2853669 polymorphism, no significant differences were detected in either genotype or allele distributions between groups (P > 0.05). CONCLUSIONS: This study suggested a positive association between TERT gene rs2736100 polymorphism and AML susceptibility in Chinese Han population. |
format | Online Article Text |
id | pubmed-7364641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73646412020-07-20 Association between TERT gene polymorphisms and acute myeloid leukemia susceptibility in a Chinese population: a case–control study Tong, Yong Xiang, Yinzhou Li, Bao Bao, Shijie Zhou, Ying Yuan, Wen Ling, Yu Hao, Dan Zhu, Huamin Sun, Zhiqiang Cancer Cell Int Primary Research BACKGROUND: The aim of this study was to investigate the association between telomerase reverse transcriptase (TERT) gene polymorphisms and acute myeloid leukemia (AML) susceptibility in a Chinese Han population. METHODS: A total of 102 AML patients and 108 healthy controls were enrolled in this case–control study. TERT gene rs2853669 and rs2736100 polymorphisms were genotyped via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Chi-square test was applied to compare polymorphism distributions between case and control groups. The strength of the association between TERT gene polymorphisms and AML susceptibility was evaluated utilizing odds ratio (OR) with corresponding 95% confidence interval (CI). RESULTS: CC genotype and C allele of rs2736100 polymorphism were more frequent in AML patients (P < 0.05), and individuals carrying CC genotype showed higher risk of suffering from AML (OR = 2.632, 95% CI 1.129–6.133). But for rs2853669 polymorphism, no significant differences were detected in either genotype or allele distributions between groups (P > 0.05). CONCLUSIONS: This study suggested a positive association between TERT gene rs2736100 polymorphism and AML susceptibility in Chinese Han population. BioMed Central 2020-07-16 /pmc/articles/PMC7364641/ /pubmed/32694935 http://dx.doi.org/10.1186/s12935-020-01335-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Primary Research Tong, Yong Xiang, Yinzhou Li, Bao Bao, Shijie Zhou, Ying Yuan, Wen Ling, Yu Hao, Dan Zhu, Huamin Sun, Zhiqiang Association between TERT gene polymorphisms and acute myeloid leukemia susceptibility in a Chinese population: a case–control study |
title | Association between TERT gene polymorphisms and acute myeloid leukemia susceptibility in a Chinese population: a case–control study |
title_full | Association between TERT gene polymorphisms and acute myeloid leukemia susceptibility in a Chinese population: a case–control study |
title_fullStr | Association between TERT gene polymorphisms and acute myeloid leukemia susceptibility in a Chinese population: a case–control study |
title_full_unstemmed | Association between TERT gene polymorphisms and acute myeloid leukemia susceptibility in a Chinese population: a case–control study |
title_short | Association between TERT gene polymorphisms and acute myeloid leukemia susceptibility in a Chinese population: a case–control study |
title_sort | association between tert gene polymorphisms and acute myeloid leukemia susceptibility in a chinese population: a case–control study |
topic | Primary Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364641/ https://www.ncbi.nlm.nih.gov/pubmed/32694935 http://dx.doi.org/10.1186/s12935-020-01335-3 |
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