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Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid

INTRODUCTION: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co‐occurring Alzheimer's disease pathology affects this relation. METHODS: In 725 memory clinic patients with SVD (mean age 67 ± 8 years, 48% female) we compared brai...

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Autores principales: Heinen, Rutger, Groeneveld, Onno N., Barkhof, Frederik, de Bresser, Jeroen, Exalto, Lieza G., Kuijf, Hugo J., Prins, Niels D., Scheltens, Philip, van der Flier, Wiesje M., Biessels, Geert Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364862/
https://www.ncbi.nlm.nih.gov/pubmed/32695872
http://dx.doi.org/10.1002/dad2.12060
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author Heinen, Rutger
Groeneveld, Onno N.
Barkhof, Frederik
de Bresser, Jeroen
Exalto, Lieza G.
Kuijf, Hugo J.
Prins, Niels D.
Scheltens, Philip
van der Flier, Wiesje M.
Biessels, Geert Jan
author_facet Heinen, Rutger
Groeneveld, Onno N.
Barkhof, Frederik
de Bresser, Jeroen
Exalto, Lieza G.
Kuijf, Hugo J.
Prins, Niels D.
Scheltens, Philip
van der Flier, Wiesje M.
Biessels, Geert Jan
author_sort Heinen, Rutger
collection PubMed
description INTRODUCTION: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co‐occurring Alzheimer's disease pathology affects this relation. METHODS: In 725 memory clinic patients with SVD (mean age 67 ± 8 years, 48% female) we compared brain volumes of those with moderate/severe white matter hyperintensities (WMHs; n = 326), lacunes (n = 132) and cerebral microbleeds (n = 321) to a reference group with mild WMHs (n = 197), also considering cerebrospinal fluid (CSF) amyloid status in a subset of patients (n = 488). RESULTS: WMHs and lacunes, but not cerebral microbleeds, were associated with smaller gray matter (GM) volumes. In analyses stratified by CSF amyloid status, WMHs and lacunes were associated with smaller total brain and GM volumes only in amyloid‐negative patients. SVD‐related atrophy was most evident in frontal (cortical) GM, again predominantly in amyloid‐negative patients. DISCUSSION: Amyloid status modifies the differential relation between SVD lesion type and brain atrophy in memory clinic patients.
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spelling pubmed-73648622020-07-20 Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid Heinen, Rutger Groeneveld, Onno N. Barkhof, Frederik de Bresser, Jeroen Exalto, Lieza G. Kuijf, Hugo J. Prins, Niels D. Scheltens, Philip van der Flier, Wiesje M. Biessels, Geert Jan Alzheimers Dement (Amst) Neuroimaging INTRODUCTION: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co‐occurring Alzheimer's disease pathology affects this relation. METHODS: In 725 memory clinic patients with SVD (mean age 67 ± 8 years, 48% female) we compared brain volumes of those with moderate/severe white matter hyperintensities (WMHs; n = 326), lacunes (n = 132) and cerebral microbleeds (n = 321) to a reference group with mild WMHs (n = 197), also considering cerebrospinal fluid (CSF) amyloid status in a subset of patients (n = 488). RESULTS: WMHs and lacunes, but not cerebral microbleeds, were associated with smaller gray matter (GM) volumes. In analyses stratified by CSF amyloid status, WMHs and lacunes were associated with smaller total brain and GM volumes only in amyloid‐negative patients. SVD‐related atrophy was most evident in frontal (cortical) GM, again predominantly in amyloid‐negative patients. DISCUSSION: Amyloid status modifies the differential relation between SVD lesion type and brain atrophy in memory clinic patients. John Wiley and Sons Inc. 2020-07-13 /pmc/articles/PMC7364862/ /pubmed/32695872 http://dx.doi.org/10.1002/dad2.12060 Text en © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Neuroimaging
Heinen, Rutger
Groeneveld, Onno N.
Barkhof, Frederik
de Bresser, Jeroen
Exalto, Lieza G.
Kuijf, Hugo J.
Prins, Niels D.
Scheltens, Philip
van der Flier, Wiesje M.
Biessels, Geert Jan
Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid
title Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid
title_full Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid
title_fullStr Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid
title_full_unstemmed Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid
title_short Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid
title_sort small vessel disease lesion type and brain atrophy: the role of co‐occurring amyloid
topic Neuroimaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364862/
https://www.ncbi.nlm.nih.gov/pubmed/32695872
http://dx.doi.org/10.1002/dad2.12060
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