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Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid
INTRODUCTION: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co‐occurring Alzheimer's disease pathology affects this relation. METHODS: In 725 memory clinic patients with SVD (mean age 67 ± 8 years, 48% female) we compared brai...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364862/ https://www.ncbi.nlm.nih.gov/pubmed/32695872 http://dx.doi.org/10.1002/dad2.12060 |
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author | Heinen, Rutger Groeneveld, Onno N. Barkhof, Frederik de Bresser, Jeroen Exalto, Lieza G. Kuijf, Hugo J. Prins, Niels D. Scheltens, Philip van der Flier, Wiesje M. Biessels, Geert Jan |
author_facet | Heinen, Rutger Groeneveld, Onno N. Barkhof, Frederik de Bresser, Jeroen Exalto, Lieza G. Kuijf, Hugo J. Prins, Niels D. Scheltens, Philip van der Flier, Wiesje M. Biessels, Geert Jan |
author_sort | Heinen, Rutger |
collection | PubMed |
description | INTRODUCTION: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co‐occurring Alzheimer's disease pathology affects this relation. METHODS: In 725 memory clinic patients with SVD (mean age 67 ± 8 years, 48% female) we compared brain volumes of those with moderate/severe white matter hyperintensities (WMHs; n = 326), lacunes (n = 132) and cerebral microbleeds (n = 321) to a reference group with mild WMHs (n = 197), also considering cerebrospinal fluid (CSF) amyloid status in a subset of patients (n = 488). RESULTS: WMHs and lacunes, but not cerebral microbleeds, were associated with smaller gray matter (GM) volumes. In analyses stratified by CSF amyloid status, WMHs and lacunes were associated with smaller total brain and GM volumes only in amyloid‐negative patients. SVD‐related atrophy was most evident in frontal (cortical) GM, again predominantly in amyloid‐negative patients. DISCUSSION: Amyloid status modifies the differential relation between SVD lesion type and brain atrophy in memory clinic patients. |
format | Online Article Text |
id | pubmed-7364862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73648622020-07-20 Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid Heinen, Rutger Groeneveld, Onno N. Barkhof, Frederik de Bresser, Jeroen Exalto, Lieza G. Kuijf, Hugo J. Prins, Niels D. Scheltens, Philip van der Flier, Wiesje M. Biessels, Geert Jan Alzheimers Dement (Amst) Neuroimaging INTRODUCTION: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co‐occurring Alzheimer's disease pathology affects this relation. METHODS: In 725 memory clinic patients with SVD (mean age 67 ± 8 years, 48% female) we compared brain volumes of those with moderate/severe white matter hyperintensities (WMHs; n = 326), lacunes (n = 132) and cerebral microbleeds (n = 321) to a reference group with mild WMHs (n = 197), also considering cerebrospinal fluid (CSF) amyloid status in a subset of patients (n = 488). RESULTS: WMHs and lacunes, but not cerebral microbleeds, were associated with smaller gray matter (GM) volumes. In analyses stratified by CSF amyloid status, WMHs and lacunes were associated with smaller total brain and GM volumes only in amyloid‐negative patients. SVD‐related atrophy was most evident in frontal (cortical) GM, again predominantly in amyloid‐negative patients. DISCUSSION: Amyloid status modifies the differential relation between SVD lesion type and brain atrophy in memory clinic patients. John Wiley and Sons Inc. 2020-07-13 /pmc/articles/PMC7364862/ /pubmed/32695872 http://dx.doi.org/10.1002/dad2.12060 Text en © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Neuroimaging Heinen, Rutger Groeneveld, Onno N. Barkhof, Frederik de Bresser, Jeroen Exalto, Lieza G. Kuijf, Hugo J. Prins, Niels D. Scheltens, Philip van der Flier, Wiesje M. Biessels, Geert Jan Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid |
title | Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid |
title_full | Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid |
title_fullStr | Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid |
title_full_unstemmed | Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid |
title_short | Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid |
title_sort | small vessel disease lesion type and brain atrophy: the role of co‐occurring amyloid |
topic | Neuroimaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364862/ https://www.ncbi.nlm.nih.gov/pubmed/32695872 http://dx.doi.org/10.1002/dad2.12060 |
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