粪菌移植治疗异基因造血干细胞移植后难治性腹泻四例报告并文献复习

OBJECTIVE: To explore the availability and safety of fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: Four acute leukemia patients suffered from refractory diarrhea after allo-HSCT. One of them was r...

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Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial office of Chinese Journal of Hematology 2019
Materias:
论著
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364982/
https://www.ncbi.nlm.nih.gov/pubmed/31775486
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.10.011
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collection PubMed
description OBJECTIVE: To explore the availability and safety of fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: Four acute leukemia patients suffered from refractory diarrhea after allo-HSCT. One of them was refractory intestinal infection, the others were intestinal graft versus host disease. One or two doses of fecal microbiota, 3.4-6.0 U for one dose, were infused via nasal-jejunal tube. The curative effect and side effects were reviewed. RESULTS: Three cases achieved complete remission while 1 was stable disease. The side effects included fever, abdominal pain and diarrhea, which all were Ⅰ grade. CONCLUSION: Fecal microbiota transplantation was effective and safe for refractory diarrhea after allo-HSCT.
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spelling pubmed-73649822020-07-16 粪菌移植治疗异基因造血干细胞移植后难治性腹泻四例报告并文献复习 Zhonghua Xue Ye Xue Za Zhi 论著 OBJECTIVE: To explore the availability and safety of fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: Four acute leukemia patients suffered from refractory diarrhea after allo-HSCT. One of them was refractory intestinal infection, the others were intestinal graft versus host disease. One or two doses of fecal microbiota, 3.4-6.0 U for one dose, were infused via nasal-jejunal tube. The curative effect and side effects were reviewed. RESULTS: Three cases achieved complete remission while 1 was stable disease. The side effects included fever, abdominal pain and diarrhea, which all were Ⅰ grade. CONCLUSION: Fecal microbiota transplantation was effective and safe for refractory diarrhea after allo-HSCT. Editorial office of Chinese Journal of Hematology 2019-10 /pmc/articles/PMC7364982/ /pubmed/31775486 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.10.011 Text en 2019年版权归中华医学会所有 http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution 3.0 License (CC-BY-NC). The Copyright own by Publisher. Without authorization, shall not reprint, except this publication article, shall not use this publication format design. Unless otherwise stated, all articles published in this journal do not represent the views of the Chinese Medical Association or the editorial board of this journal.
spellingShingle 论著
粪菌移植治疗异基因造血干细胞移植后难治性腹泻四例报告并文献复习
title 粪菌移植治疗异基因造血干细胞移植后难治性腹泻四例报告并文献复习
title_full 粪菌移植治疗异基因造血干细胞移植后难治性腹泻四例报告并文献复习
title_fullStr 粪菌移植治疗异基因造血干细胞移植后难治性腹泻四例报告并文献复习
title_full_unstemmed 粪菌移植治疗异基因造血干细胞移植后难治性腹泻四例报告并文献复习
title_short 粪菌移植治疗异基因造血干细胞移植后难治性腹泻四例报告并文献复习
title_sort 粪菌移植治疗异基因造血干细胞移植后难治性腹泻四例报告并文献复习
topic 论著
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364982/
https://www.ncbi.nlm.nih.gov/pubmed/31775486
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.10.011
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