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In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors

Outbreaks of human epidemic nonbacterial gastroenteritis are mainly caused by noroviruses. Viral replication requires a 3C-like cysteine protease (3CL(pro)) which processes the 200 kDa viral polyprotein into six functional proteins. The 3CL(pro) has attracted much interest due to its potential as a...

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Detalles Bibliográficos
Autores principales:	Guo, Jingxu, Douangamath, Alice, Song, Weixiao, Coker, Alun R., Chan, A.W. Edith, Wood, Steve P., Cooper, Jonathan B., Resnick, Efrat, London, Nir, Delft, Frank von
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365090/ https://www.ncbi.nlm.nih.gov/pubmed/32743543 http://dx.doi.org/10.1016/j.yjsbx.2020.100031

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