Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity

Prion protein (PrP) mutations are linked to genetic prion diseases, a class of phenotypically heterogeneous neurodegenerative disorders with invariably fatal outcome. How mutant PrP triggers neurodegeneration is not known. Synaptic dysfunction precedes neuronal loss but it is not clear whether, and...

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Detalles Bibliográficos
Autores principales: Ghirardini, Elsa, Restelli, Elena, Morini, Raffaella, Bertani, Ilaria, Ortolan, Davide, Perrucci, Fabio, Pozzi, Davide, Matteoli, Michela, Chiesa, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365390/
https://www.ncbi.nlm.nih.gov/pubmed/32673372
http://dx.doi.org/10.1371/journal.ppat.1008654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365390/
https://www.ncbi.nlm.nih.gov/pubmed/32673372
http://dx.doi.org/10.1371/journal.ppat.1008654

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