Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity in patients. Several transgenic animal platforms are available for the generation of fully human mAbs. Attributes such as specificity, efficacy and C...

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Detalles Bibliográficos
Autores principales: Cameron, Beatrice, Dabdoubi, Tarik, Berthou-Soulié, Laurence, Gagnaire, Marie, Arnould, Isabelle, Severac, Anne, Soubrier, Fabienne, Morales, Jacqueline, Leighton, Philip A., Harriman, William, Ching, Kathryn, Abdiche, Yasmina, Radošević, Katarina, Bouquin, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365404/
https://www.ncbi.nlm.nih.gov/pubmed/32673351
http://dx.doi.org/10.1371/journal.pone.0235815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365404/
https://www.ncbi.nlm.nih.gov/pubmed/32673351
http://dx.doi.org/10.1371/journal.pone.0235815

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