Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

A major impediment to eliminate lymphatic filariasis and onchocerciasis is the lack of effective short-course macrofilaricidal drugs or regimens that are proven to be safe for both infections. In this study we tested oxfendazole, an anthelmintic shown to be well tolerated in phase 1 clinical trials....

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Detalles Bibliográficos
Autores principales: Hübner, Marc P., Martin, Coralie, Specht, Sabine, Koschel, Marianne, Dubben, Bettina, Frohberger, Stefan J., Ehrens, Alexandra, Fendler, Martina, Struever, Dominique, Mitre, Edward, Vallarino-Lhermitte, Nathaly, Gokool, Suzanne, Lustigman, Sara, Schneider, Manfred, Townson, Simon, Hoerauf, Achim, Scandale, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365463/
https://www.ncbi.nlm.nih.gov/pubmed/32628671
http://dx.doi.org/10.1371/journal.pntd.0008427

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