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Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little i...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365470/ https://www.ncbi.nlm.nih.gov/pubmed/32673320 http://dx.doi.org/10.1371/journal.pone.0233808 |
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author | Luisi, Pierre García, Angelina Berros, Juan Manuel Motti, Josefina M. B. Demarchi, Darío A. Alfaro, Emma Aquilano, Eliana Argüelles, Carina Avena, Sergio Bailliet, Graciela Beltramo, Julieta Bravi, Claudio M. Cuello, Mariela Dejean, Cristina Dipierri, José Edgardo Jurado Medina, Laura S. Lanata, José Luis Muzzio, Marina Parolin, María Laura Pauro, Maia Paz Sepúlveda, Paula B. Rodríguez Golpe, Daniela Santos, María Rita Schwab, Marisol Silvero, Natalia Zubrzycki, Jeremias Ramallo, Virginia Dopazo, Hernán |
author_facet | Luisi, Pierre García, Angelina Berros, Juan Manuel Motti, Josefina M. B. Demarchi, Darío A. Alfaro, Emma Aquilano, Eliana Argüelles, Carina Avena, Sergio Bailliet, Graciela Beltramo, Julieta Bravi, Claudio M. Cuello, Mariela Dejean, Cristina Dipierri, José Edgardo Jurado Medina, Laura S. Lanata, José Luis Muzzio, Marina Parolin, María Laura Pauro, Maia Paz Sepúlveda, Paula B. Rodríguez Golpe, Daniela Santos, María Rita Schwab, Marisol Silvero, Natalia Zubrzycki, Jeremias Ramallo, Virginia Dopazo, Hernán |
author_sort | Luisi, Pierre |
collection | PubMed |
description | Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to perform population structure analyses at a sub-continental level. Concerning the Native American ancestry, we could identify four Native American components segregating in modern Argentinean populations. Three of them are also found in modern South American populations and are specifically represented in Central Andes, Central Chile/Patagonia, and Subtropical and Tropical Forests geographic areas. The fourth component might be specific to the Central Western region of Argentina, and it is not well represented in any genomic data from the literature. As for the European and African ancestries, we confirmed previous results about origins from Southern Europe, Western and Central Western Africa, and we provide evidences for the presence of Northern European and Eastern African ancestries. |
format | Online Article Text |
id | pubmed-7365470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-73654702020-08-05 Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina Luisi, Pierre García, Angelina Berros, Juan Manuel Motti, Josefina M. B. Demarchi, Darío A. Alfaro, Emma Aquilano, Eliana Argüelles, Carina Avena, Sergio Bailliet, Graciela Beltramo, Julieta Bravi, Claudio M. Cuello, Mariela Dejean, Cristina Dipierri, José Edgardo Jurado Medina, Laura S. Lanata, José Luis Muzzio, Marina Parolin, María Laura Pauro, Maia Paz Sepúlveda, Paula B. Rodríguez Golpe, Daniela Santos, María Rita Schwab, Marisol Silvero, Natalia Zubrzycki, Jeremias Ramallo, Virginia Dopazo, Hernán PLoS One Research Article Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to perform population structure analyses at a sub-continental level. Concerning the Native American ancestry, we could identify four Native American components segregating in modern Argentinean populations. Three of them are also found in modern South American populations and are specifically represented in Central Andes, Central Chile/Patagonia, and Subtropical and Tropical Forests geographic areas. The fourth component might be specific to the Central Western region of Argentina, and it is not well represented in any genomic data from the literature. As for the European and African ancestries, we confirmed previous results about origins from Southern Europe, Western and Central Western Africa, and we provide evidences for the presence of Northern European and Eastern African ancestries. Public Library of Science 2020-07-16 /pmc/articles/PMC7365470/ /pubmed/32673320 http://dx.doi.org/10.1371/journal.pone.0233808 Text en © 2020 Luisi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Luisi, Pierre García, Angelina Berros, Juan Manuel Motti, Josefina M. B. Demarchi, Darío A. Alfaro, Emma Aquilano, Eliana Argüelles, Carina Avena, Sergio Bailliet, Graciela Beltramo, Julieta Bravi, Claudio M. Cuello, Mariela Dejean, Cristina Dipierri, José Edgardo Jurado Medina, Laura S. Lanata, José Luis Muzzio, Marina Parolin, María Laura Pauro, Maia Paz Sepúlveda, Paula B. Rodríguez Golpe, Daniela Santos, María Rita Schwab, Marisol Silvero, Natalia Zubrzycki, Jeremias Ramallo, Virginia Dopazo, Hernán Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina |
title | Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina |
title_full | Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina |
title_fullStr | Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina |
title_full_unstemmed | Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina |
title_short | Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina |
title_sort | fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in argentina |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365470/ https://www.ncbi.nlm.nih.gov/pubmed/32673320 http://dx.doi.org/10.1371/journal.pone.0233808 |
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