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Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina

Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little i...

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Autores principales: Luisi, Pierre, García, Angelina, Berros, Juan Manuel, Motti, Josefina M. B., Demarchi, Darío A., Alfaro, Emma, Aquilano, Eliana, Argüelles, Carina, Avena, Sergio, Bailliet, Graciela, Beltramo, Julieta, Bravi, Claudio M., Cuello, Mariela, Dejean, Cristina, Dipierri, José Edgardo, Jurado Medina, Laura S., Lanata, José Luis, Muzzio, Marina, Parolin, María Laura, Pauro, Maia, Paz Sepúlveda, Paula B., Rodríguez Golpe, Daniela, Santos, María Rita, Schwab, Marisol, Silvero, Natalia, Zubrzycki, Jeremias, Ramallo, Virginia, Dopazo, Hernán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365470/
https://www.ncbi.nlm.nih.gov/pubmed/32673320
http://dx.doi.org/10.1371/journal.pone.0233808
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author Luisi, Pierre
García, Angelina
Berros, Juan Manuel
Motti, Josefina M. B.
Demarchi, Darío A.
Alfaro, Emma
Aquilano, Eliana
Argüelles, Carina
Avena, Sergio
Bailliet, Graciela
Beltramo, Julieta
Bravi, Claudio M.
Cuello, Mariela
Dejean, Cristina
Dipierri, José Edgardo
Jurado Medina, Laura S.
Lanata, José Luis
Muzzio, Marina
Parolin, María Laura
Pauro, Maia
Paz Sepúlveda, Paula B.
Rodríguez Golpe, Daniela
Santos, María Rita
Schwab, Marisol
Silvero, Natalia
Zubrzycki, Jeremias
Ramallo, Virginia
Dopazo, Hernán
author_facet Luisi, Pierre
García, Angelina
Berros, Juan Manuel
Motti, Josefina M. B.
Demarchi, Darío A.
Alfaro, Emma
Aquilano, Eliana
Argüelles, Carina
Avena, Sergio
Bailliet, Graciela
Beltramo, Julieta
Bravi, Claudio M.
Cuello, Mariela
Dejean, Cristina
Dipierri, José Edgardo
Jurado Medina, Laura S.
Lanata, José Luis
Muzzio, Marina
Parolin, María Laura
Pauro, Maia
Paz Sepúlveda, Paula B.
Rodríguez Golpe, Daniela
Santos, María Rita
Schwab, Marisol
Silvero, Natalia
Zubrzycki, Jeremias
Ramallo, Virginia
Dopazo, Hernán
author_sort Luisi, Pierre
collection PubMed
description Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to perform population structure analyses at a sub-continental level. Concerning the Native American ancestry, we could identify four Native American components segregating in modern Argentinean populations. Three of them are also found in modern South American populations and are specifically represented in Central Andes, Central Chile/Patagonia, and Subtropical and Tropical Forests geographic areas. The fourth component might be specific to the Central Western region of Argentina, and it is not well represented in any genomic data from the literature. As for the European and African ancestries, we confirmed previous results about origins from Southern Europe, Western and Central Western Africa, and we provide evidences for the presence of Northern European and Eastern African ancestries.
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spelling pubmed-73654702020-08-05 Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina Luisi, Pierre García, Angelina Berros, Juan Manuel Motti, Josefina M. B. Demarchi, Darío A. Alfaro, Emma Aquilano, Eliana Argüelles, Carina Avena, Sergio Bailliet, Graciela Beltramo, Julieta Bravi, Claudio M. Cuello, Mariela Dejean, Cristina Dipierri, José Edgardo Jurado Medina, Laura S. Lanata, José Luis Muzzio, Marina Parolin, María Laura Pauro, Maia Paz Sepúlveda, Paula B. Rodríguez Golpe, Daniela Santos, María Rita Schwab, Marisol Silvero, Natalia Zubrzycki, Jeremias Ramallo, Virginia Dopazo, Hernán PLoS One Research Article Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to perform population structure analyses at a sub-continental level. Concerning the Native American ancestry, we could identify four Native American components segregating in modern Argentinean populations. Three of them are also found in modern South American populations and are specifically represented in Central Andes, Central Chile/Patagonia, and Subtropical and Tropical Forests geographic areas. The fourth component might be specific to the Central Western region of Argentina, and it is not well represented in any genomic data from the literature. As for the European and African ancestries, we confirmed previous results about origins from Southern Europe, Western and Central Western Africa, and we provide evidences for the presence of Northern European and Eastern African ancestries. Public Library of Science 2020-07-16 /pmc/articles/PMC7365470/ /pubmed/32673320 http://dx.doi.org/10.1371/journal.pone.0233808 Text en © 2020 Luisi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Luisi, Pierre
García, Angelina
Berros, Juan Manuel
Motti, Josefina M. B.
Demarchi, Darío A.
Alfaro, Emma
Aquilano, Eliana
Argüelles, Carina
Avena, Sergio
Bailliet, Graciela
Beltramo, Julieta
Bravi, Claudio M.
Cuello, Mariela
Dejean, Cristina
Dipierri, José Edgardo
Jurado Medina, Laura S.
Lanata, José Luis
Muzzio, Marina
Parolin, María Laura
Pauro, Maia
Paz Sepúlveda, Paula B.
Rodríguez Golpe, Daniela
Santos, María Rita
Schwab, Marisol
Silvero, Natalia
Zubrzycki, Jeremias
Ramallo, Virginia
Dopazo, Hernán
Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
title Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
title_full Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
title_fullStr Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
title_full_unstemmed Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
title_short Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
title_sort fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in argentina
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365470/
https://www.ncbi.nlm.nih.gov/pubmed/32673320
http://dx.doi.org/10.1371/journal.pone.0233808
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