Role of microglia in the dissemination of Zika virus from mother to fetal brain

Global Zika virus (ZIKV) outbreaks and their link to microcephaly have raised major public health concerns. However, the mechanism of maternal-fetal transmission remains largely unknown. In this study, we determined the role of yolk sac (YS) microglial progenitors in a mouse model of ZIKV vertical t...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Pei, Shan, Chao, Dunn, Tiffany J., Xie, Xuping, Xia, Hongjie, Gao, Junling, Allende Labastida, Javier, Zou, Jing, Villarreal, Paula P., Schlagal, Caitlin R., Yu, Yongjia, Vargas, Gracie, Rossi, Shannan L., Vasilakis, Nikolaos, Shi, Pei-Yong, Weaver, Scott C., Wu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365479/
https://www.ncbi.nlm.nih.gov/pubmed/32628667
http://dx.doi.org/10.1371/journal.pntd.0008413
Descripción
Sumario:Global Zika virus (ZIKV) outbreaks and their link to microcephaly have raised major public health concerns. However, the mechanism of maternal-fetal transmission remains largely unknown. In this study, we determined the role of yolk sac (YS) microglial progenitors in a mouse model of ZIKV vertical transmission. We found that embryonic (E) days 6.5-E8.5 were a critical window for ZIKV infection that resulted in fetal demise and microcephaly, and YS microglial progenitors were susceptible to ZIKV infection. Ablation of YS microglial progenitors significantly reduced the viral load in both the YS and the embryonic brain. Taken together, these results support the hypothesis that YS microglial progenitors serve as “Trojan horses,” contributing to ZIKV fetal brain dissemination and congenital brain defects.

Ejemplares similares