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Adverse outcomes in SAR-CoV-2 (COVID-19) and SARS virus related pregnancies with probable vertical transmission
The global severe acute respiratory syndrome-related coronavirus SARS-CoV-2 (COVID-19) pandemic has had an unprecedented impact on all aspects of daily life and healthcare. Information on the infection risks for pregnant women and their offspring have so far been limited to small case series, until...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Brazilian Society of Assisted Reproduction
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365544/ https://www.ncbi.nlm.nih.gov/pubmed/32662955 http://dx.doi.org/10.5935/1518-0557.20200057 |
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author | Bahadur, Gulam Homburg, Roy Yoong, Wai Singh, Cheentan Bhat, Mamta Kotabagi, Phalguni Acharya, Santanu Huirne, Judith Doreski, Pablo Alexis Łukaszuk, Mariusz Muneer, Asif |
author_facet | Bahadur, Gulam Homburg, Roy Yoong, Wai Singh, Cheentan Bhat, Mamta Kotabagi, Phalguni Acharya, Santanu Huirne, Judith Doreski, Pablo Alexis Łukaszuk, Mariusz Muneer, Asif |
author_sort | Bahadur, Gulam |
collection | PubMed |
description | The global severe acute respiratory syndrome-related coronavirus SARS-CoV-2 (COVID-19) pandemic has had an unprecedented impact on all aspects of daily life and healthcare. Information on the infection risks for pregnant women and their offspring have so far been limited to small case series, until a large UK report on 427 SARS-CoV-2 infected pregnant women was published. Previous SARS epidemic experiences were drawn upon. Diagnostic use of real time polymerase chain reaction (RT-PCR) and IgG and IgM antibody tests are fraught with concerns of non-validation and false negative results, as are sampling methodologies. Virtually no information on controls accompany these reports. Infection of the mother and baby has serious implications for obstetric and neonatal care. Information on early and late stage pregnancy infection and the relationship to severity of infection on fetal development is both useful and clearly warranted. An increasing number of reports centre around mildly infected women showing no evidence of fetal infection while a few reports suggesting vertical transmission require further validation. Vertical transmission from mother to baby however small would have profound health implications for obstetric and neonatal care and fetal abnormalities. Some data suggesting intrapartum vertical transmission from mother to baby cannot be dismissed given the lack of controls and limitations of diagnostic viral tests. This analysis covers some key early reports addressing pregnancy outcomes following SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-7365544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Brazilian Society of Assisted Reproduction |
record_format | MEDLINE/PubMed |
spelling | pubmed-73655442020-07-21 Adverse outcomes in SAR-CoV-2 (COVID-19) and SARS virus related pregnancies with probable vertical transmission Bahadur, Gulam Homburg, Roy Yoong, Wai Singh, Cheentan Bhat, Mamta Kotabagi, Phalguni Acharya, Santanu Huirne, Judith Doreski, Pablo Alexis Łukaszuk, Mariusz Muneer, Asif JBRA Assist Reprod Review Article The global severe acute respiratory syndrome-related coronavirus SARS-CoV-2 (COVID-19) pandemic has had an unprecedented impact on all aspects of daily life and healthcare. Information on the infection risks for pregnant women and their offspring have so far been limited to small case series, until a large UK report on 427 SARS-CoV-2 infected pregnant women was published. Previous SARS epidemic experiences were drawn upon. Diagnostic use of real time polymerase chain reaction (RT-PCR) and IgG and IgM antibody tests are fraught with concerns of non-validation and false negative results, as are sampling methodologies. Virtually no information on controls accompany these reports. Infection of the mother and baby has serious implications for obstetric and neonatal care. Information on early and late stage pregnancy infection and the relationship to severity of infection on fetal development is both useful and clearly warranted. An increasing number of reports centre around mildly infected women showing no evidence of fetal infection while a few reports suggesting vertical transmission require further validation. Vertical transmission from mother to baby however small would have profound health implications for obstetric and neonatal care and fetal abnormalities. Some data suggesting intrapartum vertical transmission from mother to baby cannot be dismissed given the lack of controls and limitations of diagnostic viral tests. This analysis covers some key early reports addressing pregnancy outcomes following SARS-CoV-2 infection. Brazilian Society of Assisted Reproduction 2020 /pmc/articles/PMC7365544/ /pubmed/32662955 http://dx.doi.org/10.5935/1518-0557.20200057 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bahadur, Gulam Homburg, Roy Yoong, Wai Singh, Cheentan Bhat, Mamta Kotabagi, Phalguni Acharya, Santanu Huirne, Judith Doreski, Pablo Alexis Łukaszuk, Mariusz Muneer, Asif Adverse outcomes in SAR-CoV-2 (COVID-19) and SARS virus related pregnancies with probable vertical transmission |
title | Adverse outcomes in SAR-CoV-2 (COVID-19) and SARS virus related pregnancies with probable vertical transmission |
title_full | Adverse outcomes in SAR-CoV-2 (COVID-19) and SARS virus related pregnancies with probable vertical transmission |
title_fullStr | Adverse outcomes in SAR-CoV-2 (COVID-19) and SARS virus related pregnancies with probable vertical transmission |
title_full_unstemmed | Adverse outcomes in SAR-CoV-2 (COVID-19) and SARS virus related pregnancies with probable vertical transmission |
title_short | Adverse outcomes in SAR-CoV-2 (COVID-19) and SARS virus related pregnancies with probable vertical transmission |
title_sort | adverse outcomes in sar-cov-2 (covid-19) and sars virus related pregnancies with probable vertical transmission |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365544/ https://www.ncbi.nlm.nih.gov/pubmed/32662955 http://dx.doi.org/10.5935/1518-0557.20200057 |
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