DNA Repair Gene Mutations as Predictors of Immune Checkpoint Inhibitor Response beyond Tumor Mutation Burden

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, but prediction of their benefit is challenging. Neoantigens generated through impaired non-mismatch DNA repair may result in greater ICI activity. By analyzing 1,661 ICI-treated patients, we show that deletions and mutations in...

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Detalles Bibliográficos
Autores principales: Hsiehchen, David, Hsieh, Antony, Samstein, Robert M., Lu, Tianshi, Beg, Muhammad S., Gerber, David E., Wang, Tao, Morris, Luc G.T., Zhu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365618/
https://www.ncbi.nlm.nih.gov/pubmed/32676589
http://dx.doi.org/10.1016/j.xcrm.2020.100034

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