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Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus

The intraparietal sulcus (IPS) is structurally and functionally heterogeneous. We performed a quantitative cyto-/myelo- and receptor architectonical analysis to provide a multimodal map of the macaque IPS. We identified 17 cortical areas, including novel areas PEipe, PEipi (external and internal sub...

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Autores principales: Niu, Meiqi, Impieri, Daniele, Rapan, Lucija, Funck, Thomas, Palomero-Gallagher, Nicola, Zilles, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365665/
https://www.ncbi.nlm.nih.gov/pubmed/32613942
http://dx.doi.org/10.7554/eLife.55979
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author Niu, Meiqi
Impieri, Daniele
Rapan, Lucija
Funck, Thomas
Palomero-Gallagher, Nicola
Zilles, Karl
author_facet Niu, Meiqi
Impieri, Daniele
Rapan, Lucija
Funck, Thomas
Palomero-Gallagher, Nicola
Zilles, Karl
author_sort Niu, Meiqi
collection PubMed
description The intraparietal sulcus (IPS) is structurally and functionally heterogeneous. We performed a quantitative cyto-/myelo- and receptor architectonical analysis to provide a multimodal map of the macaque IPS. We identified 17 cortical areas, including novel areas PEipe, PEipi (external and internal subdivisions of PEip), and MIPd. Multivariate analyses of receptor densities resulted in a grouping of areas based on the degree of (dis)similarity of their receptor architecture: a cluster encompassing areas located in the posterior portion of the IPS and associated mainly with the processing of visual information, a cluster including areas found in the anterior portion of the IPS and involved in sensorimotor processing, and an ‘intermediate’ cluster of multimodal association areas. Thus, differences in cyto-/myelo- and receptor architecture segregate the cortical ribbon within the IPS, and receptor fingerprints provide novel insights into the relationship between the structural and functional segregation of this brain region in the macaque monkey.
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spelling pubmed-73656652020-07-17 Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus Niu, Meiqi Impieri, Daniele Rapan, Lucija Funck, Thomas Palomero-Gallagher, Nicola Zilles, Karl eLife Neuroscience The intraparietal sulcus (IPS) is structurally and functionally heterogeneous. We performed a quantitative cyto-/myelo- and receptor architectonical analysis to provide a multimodal map of the macaque IPS. We identified 17 cortical areas, including novel areas PEipe, PEipi (external and internal subdivisions of PEip), and MIPd. Multivariate analyses of receptor densities resulted in a grouping of areas based on the degree of (dis)similarity of their receptor architecture: a cluster encompassing areas located in the posterior portion of the IPS and associated mainly with the processing of visual information, a cluster including areas found in the anterior portion of the IPS and involved in sensorimotor processing, and an ‘intermediate’ cluster of multimodal association areas. Thus, differences in cyto-/myelo- and receptor architecture segregate the cortical ribbon within the IPS, and receptor fingerprints provide novel insights into the relationship between the structural and functional segregation of this brain region in the macaque monkey. eLife Sciences Publications, Ltd 2020-07-02 /pmc/articles/PMC7365665/ /pubmed/32613942 http://dx.doi.org/10.7554/eLife.55979 Text en © 2020, Niu et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Niu, Meiqi
Impieri, Daniele
Rapan, Lucija
Funck, Thomas
Palomero-Gallagher, Nicola
Zilles, Karl
Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus
title Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus
title_full Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus
title_fullStr Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus
title_full_unstemmed Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus
title_short Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus
title_sort receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365665/
https://www.ncbi.nlm.nih.gov/pubmed/32613942
http://dx.doi.org/10.7554/eLife.55979
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