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Is α-Amylase an Important Biomarker to Detect Aspiration of Oral Secretions in Ventilated Patients?

Alpha-amylase has emerged as a biomarker of interest in detecting aspiration of oral secretions. In several studies, most ventilated patients have α-amylase values detected in pulmonary secretions. Values of α-amylase are high (as expected) in oral secretions and lowest in bronchoalveolar lavage sam...

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Autores principales: Sole, Mary Lou, Talbert, Steven R., Rathbun, Kimberly P., Mehta, Devendra I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365705/
https://www.ncbi.nlm.nih.gov/pubmed/32766556
http://dx.doi.org/10.1097/CCE.0000000000000159
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author Sole, Mary Lou
Talbert, Steven R.
Rathbun, Kimberly P.
Mehta, Devendra I.
author_facet Sole, Mary Lou
Talbert, Steven R.
Rathbun, Kimberly P.
Mehta, Devendra I.
author_sort Sole, Mary Lou
collection PubMed
description Alpha-amylase has emerged as a biomarker of interest in detecting aspiration of oral secretions. In several studies, most ventilated patients have α-amylase values detected in pulmonary secretions. Values of α-amylase are high (as expected) in oral secretions and lowest in bronchoalveolar lavage samples. Around 5–7% of oral α-amylase is detectable in tracheal secretions. Once secretions are aspirated, the duration of detection of α-amylase in pulmonary secretions is unknown. Evidence varies on the relationship between α-amylase and clinical outcomes. Although detection of α-amylase in pulmonary secretions is useful to identify that aspiration has occurred, the lack of standardized reference values, the lack of knowledge regarding duration of detection following aspiration, and mixed findings related to clinical outcomes, limit its usefulness as a measurement tool. If α-amylase is to be used in research and/or clinical practice, additional data are needed to assist in interpretation and application of findings.
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spelling pubmed-73657052020-08-05 Is α-Amylase an Important Biomarker to Detect Aspiration of Oral Secretions in Ventilated Patients? Sole, Mary Lou Talbert, Steven R. Rathbun, Kimberly P. Mehta, Devendra I. Crit Care Explor Brief Report Alpha-amylase has emerged as a biomarker of interest in detecting aspiration of oral secretions. In several studies, most ventilated patients have α-amylase values detected in pulmonary secretions. Values of α-amylase are high (as expected) in oral secretions and lowest in bronchoalveolar lavage samples. Around 5–7% of oral α-amylase is detectable in tracheal secretions. Once secretions are aspirated, the duration of detection of α-amylase in pulmonary secretions is unknown. Evidence varies on the relationship between α-amylase and clinical outcomes. Although detection of α-amylase in pulmonary secretions is useful to identify that aspiration has occurred, the lack of standardized reference values, the lack of knowledge regarding duration of detection following aspiration, and mixed findings related to clinical outcomes, limit its usefulness as a measurement tool. If α-amylase is to be used in research and/or clinical practice, additional data are needed to assist in interpretation and application of findings. Wolters Kluwer Health 2020-07-15 /pmc/articles/PMC7365705/ /pubmed/32766556 http://dx.doi.org/10.1097/CCE.0000000000000159 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Brief Report
Sole, Mary Lou
Talbert, Steven R.
Rathbun, Kimberly P.
Mehta, Devendra I.
Is α-Amylase an Important Biomarker to Detect Aspiration of Oral Secretions in Ventilated Patients?
title Is α-Amylase an Important Biomarker to Detect Aspiration of Oral Secretions in Ventilated Patients?
title_full Is α-Amylase an Important Biomarker to Detect Aspiration of Oral Secretions in Ventilated Patients?
title_fullStr Is α-Amylase an Important Biomarker to Detect Aspiration of Oral Secretions in Ventilated Patients?
title_full_unstemmed Is α-Amylase an Important Biomarker to Detect Aspiration of Oral Secretions in Ventilated Patients?
title_short Is α-Amylase an Important Biomarker to Detect Aspiration of Oral Secretions in Ventilated Patients?
title_sort is α-amylase an important biomarker to detect aspiration of oral secretions in ventilated patients?
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365705/
https://www.ncbi.nlm.nih.gov/pubmed/32766556
http://dx.doi.org/10.1097/CCE.0000000000000159
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