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Tranilast Directly Targets NLRP3 to Protect Melanocytes From Keratinocyte-Derived IL-1β Under Oxidative Stress

The activation of NLRP3 inflammasome-IL-1β pathway in keratinocytes contributes to the melanocyte death via autoimmunity-dependent manner in vitiligo. As a safe small-compound drug employed frequently in clinic, tranilast (TR) is newly reported to block the activation of NLRP3 inflammasome in macrop...

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Detalles Bibliográficos
Autores principales:	Zhuang, Tongtian, Li, Shuli, Yi, Xiuli, Guo, Sen, Wang, Yinghan, Chen, Jianru, Liu, Ling, Jian, Zhe, Gao, Tianwen, Kang, Pan, Li, Chunying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365842/ https://www.ncbi.nlm.nih.gov/pubmed/32754591 http://dx.doi.org/10.3389/fcell.2020.00588

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