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Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication

The pathophysiology of functional gastrointestinal disorders (FGIDs) is still unclear and various complex mechanisms have been suggested to be involved. In many cases, improvement of symptoms and quality of life (QoL) in patients with FGIDs is difficult to achieve with the single-targeted treatments...

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Autores principales: Kim, Yong Sung, Kim, Jung-Wook, Ha, Na-Yeon, Kim, Jinsung, Ryu, Han Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365888/
https://www.ncbi.nlm.nih.gov/pubmed/32754057
http://dx.doi.org/10.3389/fpsyt.2020.00601
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author Kim, Yong Sung
Kim, Jung-Wook
Ha, Na-Yeon
Kim, Jinsung
Ryu, Han Seung
author_facet Kim, Yong Sung
Kim, Jung-Wook
Ha, Na-Yeon
Kim, Jinsung
Ryu, Han Seung
author_sort Kim, Yong Sung
collection PubMed
description The pathophysiology of functional gastrointestinal disorders (FGIDs) is still unclear and various complex mechanisms have been suggested to be involved. In many cases, improvement of symptoms and quality of life (QoL) in patients with FGIDs is difficult to achieve with the single-targeted treatments alone and clinical application of these treatments can be challenging owing to the side effects. Herbal preparations as complementary and alternative medicine can control multiple treatment targets of FGIDs simultaneously and relatively safely. To date, many herbal ingredients and combination preparations have been proposed across different countries and together with a variety of traditional medicine. Among the herbal therapies that are comparatively considered to have an evidence base are iberogast (STW-5) and peppermint oil, which have been mainly studied and used in Europe, and rikkunshito and motilitone (DA-9701), which are extracted from natural substances in traditional medicine, are the focus of this review. These herbal medications have multi-target pharmacology similar to the etiology of FGIDs, such as altered intestinal sensory and motor function, inflammation, neurohormonal abnormality, and have displayed comparable efficacy and safety in controlled trials. To achieve the treatment goal of refractory FGIDs, extensive and high quality studies on the pharmacological mechanisms and clinical effects of these herbal medications as well as efforts to develop new promising herbal compounds are required.
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spelling pubmed-73658882020-08-03 Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication Kim, Yong Sung Kim, Jung-Wook Ha, Na-Yeon Kim, Jinsung Ryu, Han Seung Front Psychiatry Psychiatry The pathophysiology of functional gastrointestinal disorders (FGIDs) is still unclear and various complex mechanisms have been suggested to be involved. In many cases, improvement of symptoms and quality of life (QoL) in patients with FGIDs is difficult to achieve with the single-targeted treatments alone and clinical application of these treatments can be challenging owing to the side effects. Herbal preparations as complementary and alternative medicine can control multiple treatment targets of FGIDs simultaneously and relatively safely. To date, many herbal ingredients and combination preparations have been proposed across different countries and together with a variety of traditional medicine. Among the herbal therapies that are comparatively considered to have an evidence base are iberogast (STW-5) and peppermint oil, which have been mainly studied and used in Europe, and rikkunshito and motilitone (DA-9701), which are extracted from natural substances in traditional medicine, are the focus of this review. These herbal medications have multi-target pharmacology similar to the etiology of FGIDs, such as altered intestinal sensory and motor function, inflammation, neurohormonal abnormality, and have displayed comparable efficacy and safety in controlled trials. To achieve the treatment goal of refractory FGIDs, extensive and high quality studies on the pharmacological mechanisms and clinical effects of these herbal medications as well as efforts to develop new promising herbal compounds are required. Frontiers Media S.A. 2020-07-10 /pmc/articles/PMC7365888/ /pubmed/32754057 http://dx.doi.org/10.3389/fpsyt.2020.00601 Text en Copyright © 2020 Kim, Kim, Ha, Kim and Ryu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Kim, Yong Sung
Kim, Jung-Wook
Ha, Na-Yeon
Kim, Jinsung
Ryu, Han Seung
Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication
title Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication
title_full Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication
title_fullStr Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication
title_full_unstemmed Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication
title_short Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication
title_sort herbal therapies in functional gastrointestinal disorders: a narrative review and clinical implication
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365888/
https://www.ncbi.nlm.nih.gov/pubmed/32754057
http://dx.doi.org/10.3389/fpsyt.2020.00601
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