Microglia and Their Promising Role in Ischemic Brain Injuries: An Update

Ischemic brain injuries are common diseases with high morbidity, disability, and mortality rates, which have significant impacts on human health and life. Microglia are resident cells of the central nervous system (CNS). The inflammatory responses mediated by microglia play an important role in the...

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Autores principales: Yu, Luting, Su, Xiaojuan, Li, Shiping, Zhao, Fengyan, Mu, Dezhi, Qu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365911/
https://www.ncbi.nlm.nih.gov/pubmed/32754016
http://dx.doi.org/10.3389/fncel.2020.00211
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author Yu, Luting
Su, Xiaojuan
Li, Shiping
Zhao, Fengyan
Mu, Dezhi
Qu, Yi
author_facet Yu, Luting
Su, Xiaojuan
Li, Shiping
Zhao, Fengyan
Mu, Dezhi
Qu, Yi
author_sort Yu, Luting
collection PubMed
description Ischemic brain injuries are common diseases with high morbidity, disability, and mortality rates, which have significant impacts on human health and life. Microglia are resident cells of the central nervous system (CNS). The inflammatory responses mediated by microglia play an important role in the occurrence and development of ischemic brain injuries. This article summarizes the activation, polarization, depletion, and repopulation of microglia after ischemic brain injuries, proposing new treatment strategies for such injuries through the modulation of microglial function.
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spelling pubmed-73659112020-08-03 Microglia and Their Promising Role in Ischemic Brain Injuries: An Update Yu, Luting Su, Xiaojuan Li, Shiping Zhao, Fengyan Mu, Dezhi Qu, Yi Front Cell Neurosci Cellular Neuroscience Ischemic brain injuries are common diseases with high morbidity, disability, and mortality rates, which have significant impacts on human health and life. Microglia are resident cells of the central nervous system (CNS). The inflammatory responses mediated by microglia play an important role in the occurrence and development of ischemic brain injuries. This article summarizes the activation, polarization, depletion, and repopulation of microglia after ischemic brain injuries, proposing new treatment strategies for such injuries through the modulation of microglial function. Frontiers Media S.A. 2020-07-10 /pmc/articles/PMC7365911/ /pubmed/32754016 http://dx.doi.org/10.3389/fncel.2020.00211 Text en Copyright © 2020 Yu, Su, Li, Zhao, Mu and Qu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Yu, Luting
Su, Xiaojuan
Li, Shiping
Zhao, Fengyan
Mu, Dezhi
Qu, Yi
Microglia and Their Promising Role in Ischemic Brain Injuries: An Update
title Microglia and Their Promising Role in Ischemic Brain Injuries: An Update
title_full Microglia and Their Promising Role in Ischemic Brain Injuries: An Update
title_fullStr Microglia and Their Promising Role in Ischemic Brain Injuries: An Update
title_full_unstemmed Microglia and Their Promising Role in Ischemic Brain Injuries: An Update
title_short Microglia and Their Promising Role in Ischemic Brain Injuries: An Update
title_sort microglia and their promising role in ischemic brain injuries: an update
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365911/
https://www.ncbi.nlm.nih.gov/pubmed/32754016
http://dx.doi.org/10.3389/fncel.2020.00211
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AT zhaofengyan microgliaandtheirpromisingroleinischemicbraininjuriesanupdate
AT mudezhi microgliaandtheirpromisingroleinischemicbraininjuriesanupdate
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