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Genomic Breed Composition of Selection Signatures in Brangus Beef Cattle
Cattle breeding routinely uses crossbreeding between subspecies (Bos taurus taurus and Bos taurus indicus) to form composite breeds, such as Brangus. These composite breeds provide an opportunity to identify recent selection signatures formed in the new population and evaluate the genomic compositio...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365941/ https://www.ncbi.nlm.nih.gov/pubmed/32754198 http://dx.doi.org/10.3389/fgene.2020.00710 |
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author | Paim, Tiago do Prado Hay, El Hamidi A. Wilson, Carrie Thomas, Milt G. Kuehn, Larry A. Paiva, Samuel R. McManus, Concepta Blackburn, Harvey |
author_facet | Paim, Tiago do Prado Hay, El Hamidi A. Wilson, Carrie Thomas, Milt G. Kuehn, Larry A. Paiva, Samuel R. McManus, Concepta Blackburn, Harvey |
author_sort | Paim, Tiago do Prado |
collection | PubMed |
description | Cattle breeding routinely uses crossbreeding between subspecies (Bos taurus taurus and Bos taurus indicus) to form composite breeds, such as Brangus. These composite breeds provide an opportunity to identify recent selection signatures formed in the new population and evaluate the genomic composition of these regions of the genome. Using high-density genotyping, we first identified runs of homozygosity (ROH) and calculated genomic inbreeding. Then, we evaluated the genomic composition of the regions identified as selected (selective sweeps) using a chromosome painting approach. The genomic inbreeding increased at approximately 1% per generation after composite breed formation, showing the need of inbreeding control even in composite breeds. Three selected regions in Brangus were also identified as Angus selection signatures. Two regions (chromosomes 14 and 21) were identified as signatures of selection in Brangus and both founder breeds. Five of the 10 homozygous regions in Brangus were predominantly Angus in origin (probability >80%), and the other five regions had a mixed origin but always with Brahman contributing less than 50%. Therefore, genetic events, such as drift, selection, and complementarity, are likely shaping the genetic composition of founder breeds in specific genomic regions. Such findings highlight a variety of opportunities to better control the selection process and explore heterosis and complementarity at the genomic level in composite breeds. |
format | Online Article Text |
id | pubmed-7365941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73659412020-08-03 Genomic Breed Composition of Selection Signatures in Brangus Beef Cattle Paim, Tiago do Prado Hay, El Hamidi A. Wilson, Carrie Thomas, Milt G. Kuehn, Larry A. Paiva, Samuel R. McManus, Concepta Blackburn, Harvey Front Genet Genetics Cattle breeding routinely uses crossbreeding between subspecies (Bos taurus taurus and Bos taurus indicus) to form composite breeds, such as Brangus. These composite breeds provide an opportunity to identify recent selection signatures formed in the new population and evaluate the genomic composition of these regions of the genome. Using high-density genotyping, we first identified runs of homozygosity (ROH) and calculated genomic inbreeding. Then, we evaluated the genomic composition of the regions identified as selected (selective sweeps) using a chromosome painting approach. The genomic inbreeding increased at approximately 1% per generation after composite breed formation, showing the need of inbreeding control even in composite breeds. Three selected regions in Brangus were also identified as Angus selection signatures. Two regions (chromosomes 14 and 21) were identified as signatures of selection in Brangus and both founder breeds. Five of the 10 homozygous regions in Brangus were predominantly Angus in origin (probability >80%), and the other five regions had a mixed origin but always with Brahman contributing less than 50%. Therefore, genetic events, such as drift, selection, and complementarity, are likely shaping the genetic composition of founder breeds in specific genomic regions. Such findings highlight a variety of opportunities to better control the selection process and explore heterosis and complementarity at the genomic level in composite breeds. Frontiers Media S.A. 2020-07-10 /pmc/articles/PMC7365941/ /pubmed/32754198 http://dx.doi.org/10.3389/fgene.2020.00710 Text en Copyright © 2020 Paim, Hay, Wilson, Thomas, Kuehn, Paiva, McManus and Blackburn. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Paim, Tiago do Prado Hay, El Hamidi A. Wilson, Carrie Thomas, Milt G. Kuehn, Larry A. Paiva, Samuel R. McManus, Concepta Blackburn, Harvey Genomic Breed Composition of Selection Signatures in Brangus Beef Cattle |
title | Genomic Breed Composition of Selection Signatures in Brangus Beef Cattle |
title_full | Genomic Breed Composition of Selection Signatures in Brangus Beef Cattle |
title_fullStr | Genomic Breed Composition of Selection Signatures in Brangus Beef Cattle |
title_full_unstemmed | Genomic Breed Composition of Selection Signatures in Brangus Beef Cattle |
title_short | Genomic Breed Composition of Selection Signatures in Brangus Beef Cattle |
title_sort | genomic breed composition of selection signatures in brangus beef cattle |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365941/ https://www.ncbi.nlm.nih.gov/pubmed/32754198 http://dx.doi.org/10.3389/fgene.2020.00710 |
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