Cargando…

Increased expression of ACE2, the SARS-CoV-2 entry receptor, in alveolar and bronchial epithelium of smokers and COPD subjects

This study demonstrates increased protein levels of ACE2 in alveolar and bronchial epithelium of smokers and subjects with COPD, which might facilitate host cell entry of SARS-CoV-2 https://bit.ly/2ZazOrd

Detalles Bibliográficos
Autores principales:	Jacobs, Merel, Van Eeckhoutte, Hannelore P., Wijnant, Sara R.A., Janssens, Wim, Joos, Guy F., Brusselle, Guy G., Bracke, Ken R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2020
Materias:	Agora
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366177/ https://www.ncbi.nlm.nih.gov/pubmed/32675207 http://dx.doi.org/10.1183/13993003.02378-2020

Ejemplares similares

Effect of ACE1 polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium
por: Jacobs, Merel, et al.
Publicado: (2021)

ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19
por: Leung, Janice M., et al.
Publicado: (2020)

Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication
por: Chen, Mengfei, et al.
Publicado: (2020)

Smoking, ACE-2 and COVID-19: ongoing controversies
por: Leung, Janice M., et al.
Publicado: (2020)

COVID-19 and nicotine as a mediator of ACE-2
por: Leung, Janice M., et al.
Publicado: (2020)

Could the smoking gun in the fight against COVID-19 be the (rh)ACE-2?
por: Lutchman, Dhamend
Publicado: (2020)

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences
por: Patel, Sheila K., et al.
Publicado: (2021)

COVID-19 and biologics in severe asthma: data from the Belgian Severe Asthma Registry
por: Hanon, Shane, et al.
Publicado: (2020)

mTORC1 hyperactivation in lymphangioleiomyomatosis leads to ACE2 upregulation in type II pneumocytes: implications for COVID-19
por: Tang, Yan, et al.
Publicado: (2021)

Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis
por: Mahida, Rahul Y., et al.
Publicado: (2021)

Cancer in the time of COVID-19: expert opinion on how to adapt current practice
por: Raskin, Jo, et al.
Publicado: (2020)

High-flow nasal oxygen: a safe, efficient treatment for COVID-19 patients not in an ICU
por: Guy, Tiphaine, et al.
Publicado: (2020)

P(aO(2))/F(IO(2)) ratio: the mismeasure of oxygenation in COVID-19
por: Tobin, Martin J., et al.
Publicado: (2021)

Impact of baseline patient characteristics on dupilumab efficacy in type 2 asthma
por: Busse, William W., et al.
Publicado: (2021)

Quantification and role of innate lymphoid cell subsets in Chronic Obstructive Pulmonary Disease
por: Blomme, Evy E, et al.
Publicado: (2021)

Hyperventilation as one of the mechanisms of persistent dyspnoea in SARS-CoV-2 survivors
por: Motiejunaite, Justina, et al.
Publicado: (2021)

Impact of the SARS-CoV-2 epidemic on tuberculosis treatment outcome in Northern Italy
por: Magro, Paola, et al.
Publicado: (2020)

Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2
por: Yang, Hai-Jun, et al.
Publicado: (2020)

COVID-19 and vaping: risk for increased susceptibility to SARS-CoV-2 infection?
por: McAlinden, Kielan Darcy, et al.
Publicado: (2020)

Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2
por: Du, Rong-Hui, et al.
Publicado: (2020)

Autoimmunity to annexin A2 predicts mortality among hospitalised COVID-19 patients
por: Zuniga, Marisol, et al.
Publicado: (2021)

Socioeconomic correlates of SARS-CoV-2 and influenza H1N1 outbreaks
por: Kaiser, Jan Christian, et al.
Publicado: (2020)

Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post-infection
por: Frija-Masson, Justine, et al.
Publicado: (2020)

Saliva molecular testing for SARS-CoV-2: simplifying the diagnosis without losing accuracy
por: Saluzzo, Francesca, et al.
Publicado: (2021)

Asthma, COPD and SARS-CoV-2 infection (COVID-19): potential mechanistic insights
por: Wark, Peter A.B., et al.
Publicado: (2021)

Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients
por: Yu, Hai-qiong, et al.
Publicado: (2020)

Residual symptoms and lower lung function in patients recovering from SARS-CoV-2 infection
por: Trinkmann, Frederik, et al.
Publicado: (2021)

SARS-CoV-2 disrupts clinical research: the role of a rare disease-specific trial network
por: van Koningsbruggen-Rietschel, Silke, et al.
Publicado: (2020)

Utility and safety of bronchoscopy during the SARS-CoV-2 outbreak in Italy: a retrospective, multicentre study
por: Mondoni, Michele, et al.
Publicado: (2020)

Venous thromboembolism in SARS-CoV-2 patients: only a problem in ventilated ICU patients, or is there more to it?
por: Criel, Maarten, et al.
Publicado: (2020)

SARS-CoV-2 infections in people with primary ciliary dyskinesia: neither frequent, nor particularly severe
por: Pedersen, Eva S.L., et al.
Publicado: (2021)

The association between SARS-CoV-2 RT-PCR cycle threshold and mortality in a community cohort
por: Waudby-West, Rupert, et al.
Publicado: (2021)

Characteristics and outcomes of health and social care workers testing positive for SARS-CoV-2 in the Tayside region of Scotland
por: Siddiqui, Moneeza K., et al.
Publicado: (2020)

Does chemotherapy reactivate SARS-CoV-2 in cancer patients recovered from prior COVID-19 infection?
por: Bi, Jianping, et al.
Publicado: (2020)

Responding to SARS-CoV-2 in South Africa: what can we learn from drug-resistant tuberculosis?
por: Ndjeka, Norbert, et al.
Publicado: (2020)

ORF8/ORF8a: a difference between SARS-CoV-2 and SARS-CoV
por: Zandi, Milad
Publicado: (2022)

Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial
por: Milne, Stephen, et al.
Publicado: (2021)

Wnt5a and Wnt11 as acute respiratory distress syndrome biomarkers for severe acute respiratory syndrome coronavirus 2 patients
por: Choi, Eun Young, et al.
Publicado: (2020)

A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD-0903) in severe COVID-19
por: Singh, Dave, et al.
Publicado: (2021)

Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with professional-collected nasal versus nasopharyngeal swab
por: Lindner, Andreas K., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9iimtperajduirpu9bk4s3nmar