Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg

The present study investigated the effects of electroacupuncture on blood pressure in spontaneously hypertensive rats (SHRs) by regulating the immune balance of T helper 17 cells (Th17 cells) and regulatory T cells (Treg cells). This study investigated the role of electroacupuncture in the immune ba...

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Autores principales: Wang, Yang, Zhang, Lili, Li, Li, Hu, Hantong, Pan, Pan, Zhang, Baoyu, Ning, Wenhua, Zhao, Mengxiong, Wang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366219/
https://www.ncbi.nlm.nih.gov/pubmed/32724324
http://dx.doi.org/10.1155/2020/5375981
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author Wang, Yang
Zhang, Lili
Li, Li
Hu, Hantong
Pan, Pan
Zhang, Baoyu
Ning, Wenhua
Zhao, Mengxiong
Wang, Shu
author_facet Wang, Yang
Zhang, Lili
Li, Li
Hu, Hantong
Pan, Pan
Zhang, Baoyu
Ning, Wenhua
Zhao, Mengxiong
Wang, Shu
author_sort Wang, Yang
collection PubMed
description The present study investigated the effects of electroacupuncture on blood pressure in spontaneously hypertensive rats (SHRs) by regulating the immune balance of T helper 17 cells (Th17 cells) and regulatory T cells (Treg cells). This study investigated the role of electroacupuncture in the immune balance of SHRs using Western blot, flow cytometry, and ELISA techniques. Electroacupuncture significantly improved blood pressure, downregulated the expression of RORγt, and upregulated the expression of Foxp3, reduced the production of Th17 cells, promoted the production of Treg cells, reduced the secretion of IL-6 and IL-17, and increased the secretion of TGF-β1 and IL-10. These findings suggest that electroacupuncture therapy effectively improved the systolic blood pressure of SHRs, and its mechanism may be related to promotion of the immune balance between Th17 and Treg.
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spelling pubmed-73662192020-07-27 Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg Wang, Yang Zhang, Lili Li, Li Hu, Hantong Pan, Pan Zhang, Baoyu Ning, Wenhua Zhao, Mengxiong Wang, Shu Evid Based Complement Alternat Med Research Article The present study investigated the effects of electroacupuncture on blood pressure in spontaneously hypertensive rats (SHRs) by regulating the immune balance of T helper 17 cells (Th17 cells) and regulatory T cells (Treg cells). This study investigated the role of electroacupuncture in the immune balance of SHRs using Western blot, flow cytometry, and ELISA techniques. Electroacupuncture significantly improved blood pressure, downregulated the expression of RORγt, and upregulated the expression of Foxp3, reduced the production of Th17 cells, promoted the production of Treg cells, reduced the secretion of IL-6 and IL-17, and increased the secretion of TGF-β1 and IL-10. These findings suggest that electroacupuncture therapy effectively improved the systolic blood pressure of SHRs, and its mechanism may be related to promotion of the immune balance between Th17 and Treg. Hindawi 2020-07-07 /pmc/articles/PMC7366219/ /pubmed/32724324 http://dx.doi.org/10.1155/2020/5375981 Text en Copyright © 2020 Yang Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Yang
Zhang, Lili
Li, Li
Hu, Hantong
Pan, Pan
Zhang, Baoyu
Ning, Wenhua
Zhao, Mengxiong
Wang, Shu
Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg
title Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg
title_full Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg
title_fullStr Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg
title_full_unstemmed Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg
title_short Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg
title_sort electroacupuncture improves blood pressure in shrs by regulating the immune balance between th17 and treg
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366219/
https://www.ncbi.nlm.nih.gov/pubmed/32724324
http://dx.doi.org/10.1155/2020/5375981
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