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Raoultella ornithinolytica Infection in the Pediatric Population: A Retrospective Study
Raoultella ornithinolytica is a pathogen causing an increasing number of pediatric infections. The objective of this study was to investigate the clinical characteristics of R. ornithinolytica infections in children. As a retrospective analysis, clinical features and drug susceptibility data of the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366290/ https://www.ncbi.nlm.nih.gov/pubmed/32754562 http://dx.doi.org/10.3389/fped.2020.00362 |
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author | Pi, Dan-dan Zhou, Fang Bai, Ke Liu, Chengjun Xu, Feng Li, Jing |
author_facet | Pi, Dan-dan Zhou, Fang Bai, Ke Liu, Chengjun Xu, Feng Li, Jing |
author_sort | Pi, Dan-dan |
collection | PubMed |
description | Raoultella ornithinolytica is a pathogen causing an increasing number of pediatric infections. The objective of this study was to investigate the clinical characteristics of R. ornithinolytica infections in children. As a retrospective analysis, clinical features and drug susceptibility data of the five cases were analyzed and related literature was reviewed. A total of 14 cases (eight females, six males) were analyzed: nine cases were retrieved from PubMed, Web of Science, and three domestic databases; five cases occurred in our hospital. The primary diseases of the older children were mainly of neoplastic and immune origin, while cases of infants and young children were mostly complicated by congenital malformation. Fever was the main symptom, and neonatal infection was mainly manifested by dyspnea and hypoxemia, with multiple skin flushes, systemic erythema, and leukocytosis. Of the 14 cases, six were ventilator-assisted, five had indwelling urethral catheters, three had surgical treatment or chemotherapy, and one had multiple rounds of continuous renal replacement therapy (CRRT). Blood infection is the main route of R. ornithinolytica infection in children. Skin flushing and systemic erythema might be positive clues for newborn infection. Patients with multiple congenital abnormalities are susceptible to infection. Tumors, immune deficiency, and invasive operations increase the risk of infection. Blood culture was the main method of disease identification. Based on the drug susceptibility results, the preferred antibiotics are third generations of cephalosporins, carbapenems, quinolone, and aminoglycoside. Lastly, patients with sepsis mostly have poor prognosis. |
format | Online Article Text |
id | pubmed-7366290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73662902020-08-03 Raoultella ornithinolytica Infection in the Pediatric Population: A Retrospective Study Pi, Dan-dan Zhou, Fang Bai, Ke Liu, Chengjun Xu, Feng Li, Jing Front Pediatr Pediatrics Raoultella ornithinolytica is a pathogen causing an increasing number of pediatric infections. The objective of this study was to investigate the clinical characteristics of R. ornithinolytica infections in children. As a retrospective analysis, clinical features and drug susceptibility data of the five cases were analyzed and related literature was reviewed. A total of 14 cases (eight females, six males) were analyzed: nine cases were retrieved from PubMed, Web of Science, and three domestic databases; five cases occurred in our hospital. The primary diseases of the older children were mainly of neoplastic and immune origin, while cases of infants and young children were mostly complicated by congenital malformation. Fever was the main symptom, and neonatal infection was mainly manifested by dyspnea and hypoxemia, with multiple skin flushes, systemic erythema, and leukocytosis. Of the 14 cases, six were ventilator-assisted, five had indwelling urethral catheters, three had surgical treatment or chemotherapy, and one had multiple rounds of continuous renal replacement therapy (CRRT). Blood infection is the main route of R. ornithinolytica infection in children. Skin flushing and systemic erythema might be positive clues for newborn infection. Patients with multiple congenital abnormalities are susceptible to infection. Tumors, immune deficiency, and invasive operations increase the risk of infection. Blood culture was the main method of disease identification. Based on the drug susceptibility results, the preferred antibiotics are third generations of cephalosporins, carbapenems, quinolone, and aminoglycoside. Lastly, patients with sepsis mostly have poor prognosis. Frontiers Media S.A. 2020-07-10 /pmc/articles/PMC7366290/ /pubmed/32754562 http://dx.doi.org/10.3389/fped.2020.00362 Text en Copyright © 2020 Pi, Zhou, Bai, Liu, Xu and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Pi, Dan-dan Zhou, Fang Bai, Ke Liu, Chengjun Xu, Feng Li, Jing Raoultella ornithinolytica Infection in the Pediatric Population: A Retrospective Study |
title | Raoultella ornithinolytica Infection in the Pediatric Population: A Retrospective Study |
title_full | Raoultella ornithinolytica Infection in the Pediatric Population: A Retrospective Study |
title_fullStr | Raoultella ornithinolytica Infection in the Pediatric Population: A Retrospective Study |
title_full_unstemmed | Raoultella ornithinolytica Infection in the Pediatric Population: A Retrospective Study |
title_short | Raoultella ornithinolytica Infection in the Pediatric Population: A Retrospective Study |
title_sort | raoultella ornithinolytica infection in the pediatric population: a retrospective study |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366290/ https://www.ncbi.nlm.nih.gov/pubmed/32754562 http://dx.doi.org/10.3389/fped.2020.00362 |
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