The Recent Advances of Fluorescent Sensors Based on Molecularly Imprinted Fluorescent Nanoparticles for Pharmaceutical Analysis

Fluorescent nanoparticles have good chemical stability and photostability, controllable optical properties and larger stokes shift. In light of their designability and functionability, the fluorescent nanoparticles are widely used as the fluorescent probes for diverse applications. To enhance the sensitivity and selectivity, the combination of the fluorescent nanoparticles with the molecularly imprinted polymer, i.e. molecularly imprinted fluorescent nanoparticles (MIFN), was an effective way. The sensor based on MIFN (the MIFN sensor) could be more compatible with the complex sample matrix, which was especially widely adopted in medical and biological analysis. In this mini-review, the construction method, detective mechanism and types of MIFN sensors are elaborated. The current applications of MIFN sensors in pharmaceutical analysis, including pesticides/herbicide, veterinary drugs/drugs residues and human related proteins, are highlighted based on the literature in the recent three years. Finally, the research prospect and development trend of the MIFN sensor are forecasted.