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The Effect of Five-Day Dry Immersion on the Nervous and Metabolic Mechanisms of the Circulatory System
The purpose of the study was to investigate the regulatory and metabolic changes in the circulatory system when simulating microgravity conditions in a five-day dry immersion. These changes reflect the adaptation processes characteristic for the initial stages of a space flight or a short-duration s...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366513/ https://www.ncbi.nlm.nih.gov/pubmed/32754043 http://dx.doi.org/10.3389/fphys.2020.00692 |
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author | Rusanov, Vasily B. Pastushkova, Ludmila Kh. Larina, Irina M. Chernikova, Anna G. Goncharova, Anna G. Nosovsky, Andrei M. Kashirina, Daria N. Brzhozovsky, Alexander G. Navasiolava, Nastassia Kononikhin, Alexey S. Kussmaul, Anna R. Custaud, Marc-Antoine Nikolaev, Evgeny N. |
author_facet | Rusanov, Vasily B. Pastushkova, Ludmila Kh. Larina, Irina M. Chernikova, Anna G. Goncharova, Anna G. Nosovsky, Andrei M. Kashirina, Daria N. Brzhozovsky, Alexander G. Navasiolava, Nastassia Kononikhin, Alexey S. Kussmaul, Anna R. Custaud, Marc-Antoine Nikolaev, Evgeny N. |
author_sort | Rusanov, Vasily B. |
collection | PubMed |
description | The purpose of the study was to investigate the regulatory and metabolic changes in the circulatory system when simulating microgravity conditions in a five-day dry immersion. These changes reflect the adaptation processes characteristic for the initial stages of a space flight or a short-duration space flight. Studies were conducted with 13 healthy male volunteers aged 21 to 29 years. The assessment of regulatory and metabolic processes in the circulatory system was based on the heart rate variability (HRV) and urine proteomic profile analysis. It was found that the restructuring of hemodynamics during 5 days hypogravity begins with the inclusion of the nervous circuit of regulation, and for manifestations at the body fluids protein composition level and activation of the metabolic regulation, these periods are apparently insufficient. Perhaps this is due to the fact that the metabolic regulation, being evolutionarily ancient and genetically determined, is more stable and requires more time for its pronounced activation when stimulated by extreme life conditions. |
format | Online Article Text |
id | pubmed-7366513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73665132020-08-03 The Effect of Five-Day Dry Immersion on the Nervous and Metabolic Mechanisms of the Circulatory System Rusanov, Vasily B. Pastushkova, Ludmila Kh. Larina, Irina M. Chernikova, Anna G. Goncharova, Anna G. Nosovsky, Andrei M. Kashirina, Daria N. Brzhozovsky, Alexander G. Navasiolava, Nastassia Kononikhin, Alexey S. Kussmaul, Anna R. Custaud, Marc-Antoine Nikolaev, Evgeny N. Front Physiol Physiology The purpose of the study was to investigate the regulatory and metabolic changes in the circulatory system when simulating microgravity conditions in a five-day dry immersion. These changes reflect the adaptation processes characteristic for the initial stages of a space flight or a short-duration space flight. Studies were conducted with 13 healthy male volunteers aged 21 to 29 years. The assessment of regulatory and metabolic processes in the circulatory system was based on the heart rate variability (HRV) and urine proteomic profile analysis. It was found that the restructuring of hemodynamics during 5 days hypogravity begins with the inclusion of the nervous circuit of regulation, and for manifestations at the body fluids protein composition level and activation of the metabolic regulation, these periods are apparently insufficient. Perhaps this is due to the fact that the metabolic regulation, being evolutionarily ancient and genetically determined, is more stable and requires more time for its pronounced activation when stimulated by extreme life conditions. Frontiers Media S.A. 2020-07-10 /pmc/articles/PMC7366513/ /pubmed/32754043 http://dx.doi.org/10.3389/fphys.2020.00692 Text en Copyright © 2020 Rusanov, Pastushkova, Larina, Chernikova, Goncharova, Nosovsky, Kashirina, Brzhozovsky, Navasiolava, Kononikhin, Kussmaul, Custaud and Nikolaev. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Rusanov, Vasily B. Pastushkova, Ludmila Kh. Larina, Irina M. Chernikova, Anna G. Goncharova, Anna G. Nosovsky, Andrei M. Kashirina, Daria N. Brzhozovsky, Alexander G. Navasiolava, Nastassia Kononikhin, Alexey S. Kussmaul, Anna R. Custaud, Marc-Antoine Nikolaev, Evgeny N. The Effect of Five-Day Dry Immersion on the Nervous and Metabolic Mechanisms of the Circulatory System |
title | The Effect of Five-Day Dry Immersion on the Nervous and Metabolic Mechanisms of the Circulatory System |
title_full | The Effect of Five-Day Dry Immersion on the Nervous and Metabolic Mechanisms of the Circulatory System |
title_fullStr | The Effect of Five-Day Dry Immersion on the Nervous and Metabolic Mechanisms of the Circulatory System |
title_full_unstemmed | The Effect of Five-Day Dry Immersion on the Nervous and Metabolic Mechanisms of the Circulatory System |
title_short | The Effect of Five-Day Dry Immersion on the Nervous and Metabolic Mechanisms of the Circulatory System |
title_sort | effect of five-day dry immersion on the nervous and metabolic mechanisms of the circulatory system |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366513/ https://www.ncbi.nlm.nih.gov/pubmed/32754043 http://dx.doi.org/10.3389/fphys.2020.00692 |
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