Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPM(PZQ) by PZQ, enhanced Ca(++) influx, spastic paralysis, and tegumental disrupture—the deadly cascade in parasitic schistosomes, other trematodes, and cestodes

After almost 50 years of praziquantel (PZQ) research, Park and Marchant (Trends Parasitol 36:182–194, 2020) described the Ca(++)-permeable transient receptor potential (TRP) channel Sm.TRPM(PZQ) in Schistosoma mansoni as target of PZQ. Here we describe the deadly cascade in schistosomes which is ind...

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Detalles Bibliográficos
Autor principal: Harder, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Helminthology - Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366562/
https://www.ncbi.nlm.nih.gov/pubmed/32607709
http://dx.doi.org/10.1007/s00436-020-06763-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366562/
https://www.ncbi.nlm.nih.gov/pubmed/32607709
http://dx.doi.org/10.1007/s00436-020-06763-8

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