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Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPM(PZQ) by PZQ, enhanced Ca(++) influx, spastic paralysis, and tegumental disrupture—the deadly cascade in parasitic schistosomes, other trematodes, and cestodes
After almost 50 years of praziquantel (PZQ) research, Park and Marchant (Trends Parasitol 36:182–194, 2020) described the Ca(++)-permeable transient receptor potential (TRP) channel Sm.TRPM(PZQ) in Schistosoma mansoni as target of PZQ. Here we describe the deadly cascade in schistosomes which is ind...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366562/ https://www.ncbi.nlm.nih.gov/pubmed/32607709 http://dx.doi.org/10.1007/s00436-020-06763-8 |