Genetically modified macrophages accomplish targeted gene delivery to the inflamed brain in transgenic Parkin Q311X(A) mice: importance of administration routes

Cell-based drug delivery systems have generated an increasing interest in recent years. We previously demonstrated that systemically administered macrophages deliver therapeutics to CNS, including glial cell line-derived neurotrophic factor (GDNF), and produce potent effects in Parkinson’s disease (...

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Detalles Bibliográficos
Autores principales: Haney, Matthew J., Zhao, Yuling, Fay, James, Duhyeong, Hwang, Wang, Mengzhe, Wang, Hui, Li, Zibo, Lee, Yueh Z., Karuppan, Mohan K., El-Hage, Nazira, Kabanov, Alexander V., Batrakova, Elena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366622/
https://www.ncbi.nlm.nih.gov/pubmed/32678262
http://dx.doi.org/10.1038/s41598-020-68874-7

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