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Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice

The digestive enzyme chymotrypsin protects the pancreas against pancreatitis by reducing harmful trypsin activity. Genetic deficiency in chymotrypsin increases pancreatitis risk in humans and pancreatitis severity in mice. Pancreatic chymotrypsin is produced in multiple isoforms including chymotryps...

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Detalles Bibliográficos
Autores principales:	Mosztbacher, Dóra, Jancsó, Zsanett, Sahin-Tóth, Miklós
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366634/ https://www.ncbi.nlm.nih.gov/pubmed/32678161 http://dx.doi.org/10.1038/s41598-020-68616-9

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