Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin

Neutrophils are pivotal players in immune defence which includes a process of release of histones and DNA as neutrophil extracellular traps (NETs). Histones, while toxic to invading pathogens, also kill host cells, including neutrophils. Bacteria have evolved mechanisms to escape neutrophils, includ...

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Detalles Bibliográficos
Autores principales: Locke, Matthew, Francis, Robert J., Tsaousi, Evgenia, Longstaff, Colin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366688/
https://www.ncbi.nlm.nih.gov/pubmed/32678135
http://dx.doi.org/10.1038/s41598-020-68584-0

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