The integrated stress response induces R-loops and hinders replication fork progression

The integrated stress response (ISR) allows cells to rapidly shutdown most of their protein synthesis in response to protein misfolding, amino acid deficiency, or virus infection. These stresses trigger the phosphorylation of the translation initiation factor eIF2alpha, which prevents the initiation...

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Detalles Bibliográficos
Autores principales: Choo, Josephine Ann Mun Yee, Schlösser, Denise, Manzini, Valentina, Magerhans, Anna, Dobbelstein, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366693/
https://www.ncbi.nlm.nih.gov/pubmed/32678076
http://dx.doi.org/10.1038/s41419-020-2727-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366693/
https://www.ncbi.nlm.nih.gov/pubmed/32678076
http://dx.doi.org/10.1038/s41419-020-2727-2

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