Cargando…

Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways

BACKGROUND: The aim of this study was to explore whether letrozole and high-fat diets (HFD) can induce obese insulin-resistant polycystic ovary syndrome (PCOS) with all reproductive and metabolic phenotypes in a rat model. MATERIAL/METHODS: Twenty-four 3-week-old female Sprague-Dawley rats were rand...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Jinbang, Dun, Jingjing, Yang, Juan, Zhang, Junxin, Lin, Qiuping, Huang, Mingqing, Ji, Feng, Huang, Lishan, You, Xiumi, Lin, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2020
Materias:	Animal Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366789/ https://www.ncbi.nlm.nih.gov/pubmed/32638705 http://dx.doi.org/10.12659/MSM.923073

Ejemplares similares

A Rat Model of Polycystic Ovary Syndrome with Insulin Resistance Induced by Letrozole Combined with High Fat Diet
por: Wang, Ming-Xing, et al.
Publicado: (2020)

The Flavanone, Naringenin, Modifies Antioxidant and Steroidogenic Enzyme Activity in a Rat Model of Letrozole-Induced Polycystic Ovary Syndrome
por: Hong, Yanli, et al.
Publicado: (2019)

Association between heavy metals exposure and infertility among American women aged 20–44 years: A cross-sectional analysis from 2013 to 2018 NHANES data
por: Lin, Jie, et al.
Publicado: (2023)

Effect of Dexmedetomidine-Mediated Insulin-Like Growth Factor 2 (IGF2) Signal Pathway on Immune Function and Invasion and Migration of Cancer Cells in Rats with Ovarian Cancer
por: Tian, Hang, et al.
Publicado: (2019)

Phyllanthus muellerianus (Euphorbiaceae) Restores Ovarian Functions in Letrozole-Induced Polycystic Ovarian Syndrome in Rats
por: Ndeingang, Eveline Christiane, et al.
Publicado: (2019)

Strontium Ranelate Combined with Insulin Is as Beneficial as Insulin Alone in Treatment of Fracture Healing in Ovariectomized Diabetic Rats
por: Cao, Guo-Long, et al.
Publicado: (2018)

Rhamnocitrin Attenuates Ovarian Fibrosis in Rats with Letrozole-Induced Experimental Polycystic Ovary Syndrome
por: Zhou, Yanyuan, et al.
Publicado: (2022)

A multicenter randomized trial of personalized acupuncture, fixed acupuncture, letrozole, and placebo letrozole on live birth in infertile women with polycystic ovary syndrome
por: Huang, Shiya, et al.
Publicado: (2020)

Comparison of ovulation induction with letrozole plus dexamethasone and letrozole alone in infertile women with polycystic ovarian disease: An RCT
por: Farzaneh, Farahnaz, et al.
Publicado: (2020)

Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model
por: Maharjan, Radha, et al.
Publicado: (2010)

A Rat Model of Maternal Polycystic Ovary Syndrome Shows that Exposure to Androgens In Utero Results in Dysbiosis of the Intestinal Microbiota and Metabolic Disorders of the Newborn Rat
por: Gulan, Tuohetimulati, et al.
Publicado: (2019)

Assessment of Fertility Outcomes Following Combined Clomiphene and Letrozole Versus Letrozole Therapy for the Treatment of Polycystic Ovarian Syndrome Subfertility
por: Sharma, Priyanka, et al.
Publicado: (2023)

Agaricus Subrufescens ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with Letrozole induced polycystic ovarian syndrome
por: Bukke, Sarad Pawar Naik, et al.
Publicado: (2023)

Effects of Metformin on Reproductive, Endocrine, and Metabolic Characteristics of Female Offspring in a Rat Model of Letrozole-Induced Polycystic Ovarian Syndrome With Insulin Resistance
por: Xie, Yidong, et al.
Publicado: (2021)

Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats
por: Ullah, Asad, et al.
Publicado: (2017)

Effects of Electroacupuncture on Ovarian Expression of the Androgen Receptor and Connexin 43 in Rats with Letrozole-Induced Polycystic Ovaries
por: Xu, Ge, et al.
Publicado: (2020)

Regulation of estrous cycle by Cynodon dactylon in letrozole induced polycystic ovarian syndrome in Wistars albino rats
por: Nallathambi, Anandaramajayan, et al.
Publicado: (2019)

Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats
por: Haslan, Muhammad Aliff, et al.
Publicado: (2021)

Effects of Fagonia indica on Letrozole-Induced Polycystic Ovarian Syndrome (PCOS) in Young Adult Female Rats
por: Younas, Anam, et al.
Publicado: (2022)

Effect of Vitex negundo L. seeds in letrozole induced polycystic ovarian syndrome
por: Kakadia, Nimisha, et al.
Publicado: (2018)

Beneficial effect of polyherbal formulation in letrozole induced Polycystic ovarian syndrome (PCOS)
por: Prajapati, Disha P., et al.
Publicado: (2022)

Evaluation of the Effects of Caesalpinia crista on Letrozole-Induced Models of Polycystic Ovarian Syndrome
por: Shende, Anagha, et al.
Publicado: (2023)

Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats
por: Saiyed, Amrin, et al.
Publicado: (2016)

Melatonin as a promising therapeutic intervention for restoring ovarian function in letrozole-induced polycystic ovary syndrome rats
por: Basheer, Muddasir, et al.
Publicado: (2023)

Letrozole cotreatment with progestin-primed ovarian stimulation in women with polycystic ovary syndrome undergoing IVF treatment
por: Liu, Yali, et al.
Publicado: (2022)

Serum Proteomic Profiling Analysis of Rats Chronically Exposed to Arsenic
por: Zhang, Ling, et al.
Publicado: (2019)

Mimic Cochlear Implant Surgery-Induced Cochlear Infection Fails to Further Damage Auditory Pathway in Deafened Guinea Pigs
por: Han, Zhao, et al.
Publicado: (2018)

Efficacy of letrozole versus clomiphene citrate on ovulation induction in patients with polycystic ovarian syndrome
por: Khakwani, Mehnaz, et al.
Publicado: (2022)

Short Hairpin Ribonucleic Acid Constructs Targeting Insulin-like Growth Factor Binding Protein-3 Reversed Decreased Testosterone Concentrations in Diabetic Rats
por: Zhou, Zhang-Yan, et al.
Publicado: (2015)

Eicosapentaenoic Acid Improves Polycystic Ovary Syndrome in Rats via Sterol Regulatory Element-Binding Protein 1 (SREBP-1)/Toll-Like Receptor 4 (TLR4) Pathway
por: Wang, Yanting, et al.
Publicado: (2018)

Toll-Like Receptor 4 (TLR4) Stimulates Synovial Injury of Temporomandibular Joint in Rats Through the Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway
por: Lin, Xuefen, et al.
Publicado: (2018)

The Use of High Dose Letrozole in Ovulation Induction and Controlled Ovarian Hyperstimulation
por: Pritts, Elizabeth A., et al.
Publicado: (2011)

Phytochemical-Based Study of Ethanolic Extract of Saraca asoca in Letrozole-Induced Polycystic Ovarian Syndrome in Female Adult Rats
por: Bu, Na, et al.
Publicado: (2023)

The Effect of Interleukin-6 (IL-6), Interleukin-11 (IL-11), Signal Transducer and Activator of Transcription 3 (STAT3), and AKT Signaling on Adipocyte Proliferation in a Rat Model of Polycystic Ovary Syndrome
por: Zhuang, Zhaohui, et al.
Publicado: (2019)

Preoperative Oral Carbohydrate Improved Postoperative Insulin Resistance in Rats through the PI3K/AKT/mTOR Pathway
por: Wang, Zhiguo, et al.
Publicado: (2015)

Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome
por: Hajishafiha, Masomeh, et al.
Publicado: (2013)

Comparison of Letrozole Versus Tamoxifen Effects in Clomiphen Citrate Resistant Women with Polycystic Ovarian Syndrome
por: EL-Gharib, Mohamed Nabih, et al.
Publicado: (2015)

Dosage Optimization for Letrozole Treatment in Clomiphene-Resistant Patients with Polycystic Ovary Syndrome: A Prospective Interventional Study
por: Rahmani, Elham, et al.
Publicado: (2012)

Effects of Long-Term Exercise on Spatial Learning, Memory Ability, and Cortical Capillaries in Aged Rats
por: Wang, Sanrong, et al.
Publicado: (2015)

Association of Bactericidal Dysfunction of Paneth Cells in Streptozocin-Induced Diabetic Mice with Insulin Deficiency
por: Yu, Tao, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8t6p79dk3dsdahcsr5pg0a25r2