Cargando…

Treating Protein Misfolding Diseases: Therapeutic Successes Against Systemic Amyloidoses

Misfolding and extracellular deposition of proteins is the hallmark of a heterogeneous group of conditions collectively termed protein misfolding and deposition diseases or amyloidoses. These include both localized (e.g. Alzheimer’s disease, prion diseases, type 2 diabetes mellitus) and systemic amy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nevone, Alice, Merlini, Giampaolo, Nuvolone, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366848/ https://www.ncbi.nlm.nih.gov/pubmed/32754033 http://dx.doi.org/10.3389/fphar.2020.01024

Ejemplares similares

Targeting Amyloid Fibrils by Passive Immunotherapy in Systemic Amyloidosis
por: Nuvolone, Mario, et al.
Publicado: (2022)

Systemic amyloidoses and proteomics: The state of the art
por: Lavatelli, Francesca, et al.
Publicado: (2016)

Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses
por: Galant, Natalie J., et al.
Publicado: (2016)

Corrigendum: Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses
por: Galant, Natalie J., et al.
Publicado: (2016)

Patient experience with hereditary and senile systemic amyloidoses: a survey from the Amyloidosis Research Consortium
por: Lousada, Isabelle, et al.
Publicado: (2015)

Advances in diagnostics and therapy of systemic amyloidoses
por: Jamroziak, Krzysztof, et al.
Publicado: (2020)

A Strategy for the Selection of RT-qPCR Reference Genes Based on Publicly Available Transcriptomic Datasets
por: Nevone, Alice, et al.
Publicado: (2023)

Structure of Tau filaments in Prion protein amyloidoses
por: Hallinan, Grace I., et al.
Publicado: (2021)

Enzymatic remodeling of heparan sulfate: a therapeutic strategy for systemic and localized amyloidoses?
por: Nishitsuji, Kazuchika, et al.
Publicado: (2016)

Oxidative Stress, Chronic Inflammation, and Amyloidoses
por: Orzechowski, Arkadiusz, et al.
Publicado: (2019)

Amyloïdose induite par l’insuline
por: Kano, Yasuhiro
Publicado: (2023)

Oral Therapy for the Treatment of Transthyretin-Related Amyloid Cardiomyopathy
por: Nuvolone, Mario, et al.
Publicado: (2022)

DES-Amyloidoses “Amyloidoses through the looking-glass”: A knowledgebase developed for exploring and linking information related to human amyloid-related diseases
por: Bajic, Vladan P., et al.
Publicado: (2022)

Stress Response Is the Main Trigger of Sporadic Amyloidoses
por: Galkin, Alexey P., et al.
Publicado: (2021)

Kardiale Amyloidose: Aktuelle und zukünftige Therapieoptionen
por: Knoll, Katharina, et al.
Publicado: (2023)

P823: BONE MARROW-FREE SEQUENCING OF M PROTEIN GENES IN MONOCLONAL GAMMOPATHIES
por: Nevone, Alice, et al.
Publicado: (2023)

Amyloïdose féline à expression hépatique chez 2 chats()
por: Derré, G., et al.
Publicado: (2014)

A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses
por: Zha, Jun, et al.
Publicado: (2016)

Dual Blockade of Misfolded Alpha-Sarcoglycan Degradation by Bortezomib and Givinostat Combination
por: Hoch, Lucile, et al.
Publicado: (2022)

Protein misfolding diseases
por: Ventura, Salvador
Publicado: (2015)

Role of Protein Misfolding and Proteostasis Deficiency in Protein Misfolding Diseases and Aging
por: Cuanalo-Contreras, Karina, et al.
Publicado: (2013)

The Importance of a Gatekeeper Residue on the Aggregation of Transthyretin: IMPLICATIONS FOR TRANSTHYRETIN-RELATED AMYLOIDOSES
por: Sant'Anna, Ricardo, et al.
Publicado: (2014)

Amyloidoses in Onco-Nephrology Practice: A Multidisciplinary Case-Based Conference Report
por: Kitchlu, Abhijat, et al.
Publicado: (2023)

Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
por: Ciechanover, Aaron, et al.
Publicado: (2015)

Protein Misfolding and Aggregation as a Therapeutic Target for Polyglutamine Diseases
por: Takeuchi, Toshihide, et al.
Publicado: (2017)

Cross-Seeding of Misfolded Proteins: Implications for Etiology and Pathogenesis of Protein Misfolding Diseases
por: Morales, Rodrigo, et al.
Publicado: (2013)

Lessons from two prevalent amyloidoses—what amylin and Aβ have in common
por: Götz, Jürgen, et al.
Publicado: (2013)

Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses
por: Yee, Ai Woon, et al.
Publicado: (2016)

Protein Misfolding and Neurodegenerative Diseases
por: Cardinale, Alessio, et al.
Publicado: (2014)

Protein Misfolding and Human Disease
por: Dobson, Christopher
Publicado: (2002)

Unraveling protein misfolding diseases using model systems
por: Peffer, Sara, et al.
Publicado: (2015)

Pharmacoperone Identification for Therapeutic Rescue of Misfolded Mutant Proteins
por: Conn, P. Michael, et al.
Publicado: (2011)

Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers
por: Kreiser, Ryan P., et al.
Publicado: (2020)

The Structural Understanding of Transthyretin Misfolding and the Inspired Drug Approaches for the Treatment of Heart Failure Associated With Transthyretin Amyloidosis
por: He, Shan, et al.
Publicado: (2021)

Diverse Misfolded Conformational Strains and Cross-seeding of Misfolded Proteins Implicated in Neurodegenerative Diseases
por: Lim, Kwang Hun
Publicado: (2019)

Prion Protein Misfolding
por: Kupfer, L, et al.
Publicado: (2009)

Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases
por: de Souza, Jessica M., et al.
Publicado: (2018)

Editorial: Novel therapeutic approaches to treat neuroinflammation in the central nervous system
por: German, Nadezhda A.
Publicado: (2023)

Indicators of profound hematologic response in AL amyloidosis: complete response remains the goal of therapy
por: Milani, Paolo, et al.
Publicado: (2020)

Membrane Interactions and Toxicity by Misfolded Protein Oligomers
por: Gonzalez-Garcia, Mario, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7vr1qveumdmlmla0eshib6scro