Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype

The clinically important MAM blood group antigen is present on haematopoietic cells of all humans except rare MAM-negative individuals. Its molecular basis is unknown. By whole-exome sequencing we identify EMP3, encoding epithelial membrane protein 3 (EMP3), as a candidate gene, then demonstrate ina...

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Detalles Bibliográficos
Autores principales: Thornton, Nicole, Karamatic Crew, Vanja, Tilley, Louise, Green, Carole A., Tay, Chwen Ling, Griffiths, Rebecca E., Singleton, Belinda K., Spring, Frances, Walser, Piers, Alattar, Abdul Ghani, Jones, Benjamin, Laundy, Rosalind, Storry, Jill R., Möller, Mattias, Wall, Lorna, Charlewood, Richard, Westhoff, Connie M., Lomas-Francis, Christine, Yahalom, Vered, Feick, Ute, Seltsam, Axel, Mayer, Beate, Olsson, Martin L., Anstee, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366909/
https://www.ncbi.nlm.nih.gov/pubmed/32678083
http://dx.doi.org/10.1038/s41467-020-17060-4

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