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A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics
The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366937/ https://www.ncbi.nlm.nih.gov/pubmed/32678265 http://dx.doi.org/10.1038/s41598-020-68864-9 |
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author | Choi, Seung-Min Jeong, Jae-Chan Kim, Jinsun Lim, Eul-Gyoon Kim, Chang-beom Park, Sang-Jin Song, Dae-Yong Krause, Hans-Joachim Hong, Hyobong Kweon, In So |
author_facet | Choi, Seung-Min Jeong, Jae-Chan Kim, Jinsun Lim, Eul-Gyoon Kim, Chang-beom Park, Sang-Jin Song, Dae-Yong Krause, Hans-Joachim Hong, Hyobong Kweon, In So |
author_sort | Choi, Seung-Min |
collection | PubMed |
description | The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is [Formula: see text] in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is [Formula: see text] , 10 mg/mL, [Formula: see text] (Fe). |
format | Online Article Text |
id | pubmed-7366937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73669372020-07-20 A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics Choi, Seung-Min Jeong, Jae-Chan Kim, Jinsun Lim, Eul-Gyoon Kim, Chang-beom Park, Sang-Jin Song, Dae-Yong Krause, Hans-Joachim Hong, Hyobong Kweon, In So Sci Rep Article The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is [Formula: see text] in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is [Formula: see text] , 10 mg/mL, [Formula: see text] (Fe). Nature Publishing Group UK 2020-07-16 /pmc/articles/PMC7366937/ /pubmed/32678265 http://dx.doi.org/10.1038/s41598-020-68864-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Choi, Seung-Min Jeong, Jae-Chan Kim, Jinsun Lim, Eul-Gyoon Kim, Chang-beom Park, Sang-Jin Song, Dae-Yong Krause, Hans-Joachim Hong, Hyobong Kweon, In So A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics |
title | A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics |
title_full | A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics |
title_fullStr | A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics |
title_full_unstemmed | A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics |
title_short | A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics |
title_sort | novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366937/ https://www.ncbi.nlm.nih.gov/pubmed/32678265 http://dx.doi.org/10.1038/s41598-020-68864-9 |
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