Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma

Anti-low-density lipoprotein receptor-related lipoprotein 2 (LRP2) nephropathy/anti-brush border antibody disease is rare and characterized by tubular basement membrane, Bowman’s capsule and glomerular subepithelial immune deposits on kidney biopsy. No reported cases have occurred in patients with l...

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Autores principales: Gamayo, Ashley, Hecox, Douglas, Dicker, Lance, Vecchiarelli, Lisa, Raess, Philipp W, Khalighi, Mazdak, Andeen, Nicole K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Exceptional Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367117/
https://www.ncbi.nlm.nih.gov/pubmed/32701074
http://dx.doi.org/10.1093/ckj/sfz166
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author Gamayo, Ashley
Hecox, Douglas
Dicker, Lance
Vecchiarelli, Lisa
Raess, Philipp W
Khalighi, Mazdak
Andeen, Nicole K
author_facet Gamayo, Ashley
Hecox, Douglas
Dicker, Lance
Vecchiarelli, Lisa
Raess, Philipp W
Khalighi, Mazdak
Andeen, Nicole K
author_sort Gamayo, Ashley
collection PubMed
description Anti-low-density lipoprotein receptor-related lipoprotein 2 (LRP2) nephropathy/anti-brush border antibody disease is rare and characterized by tubular basement membrane, Bowman’s capsule and glomerular subepithelial immune deposits on kidney biopsy. No reported cases have occurred in patients with lymphoproliferative disorders or monoclonal gammopathies. We present two cases of anti-LRP2 nephropathy that occurred in patients with progressive low-grade B-cell lymphoma and had concurrent kidney infiltration by lymphoma on biopsy. We speculate that underlying immune dysregulation related to lymphoma may contribute to the development of this rare autoimmune kidney disease in some patients.
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spelling pubmed-73671172020-07-21 Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma Gamayo, Ashley Hecox, Douglas Dicker, Lance Vecchiarelli, Lisa Raess, Philipp W Khalighi, Mazdak Andeen, Nicole K Clin Kidney J Exceptional Cases Anti-low-density lipoprotein receptor-related lipoprotein 2 (LRP2) nephropathy/anti-brush border antibody disease is rare and characterized by tubular basement membrane, Bowman’s capsule and glomerular subepithelial immune deposits on kidney biopsy. No reported cases have occurred in patients with lymphoproliferative disorders or monoclonal gammopathies. We present two cases of anti-LRP2 nephropathy that occurred in patients with progressive low-grade B-cell lymphoma and had concurrent kidney infiltration by lymphoma on biopsy. We speculate that underlying immune dysregulation related to lymphoma may contribute to the development of this rare autoimmune kidney disease in some patients. Oxford University Press 2019-12-22 /pmc/articles/PMC7367117/ /pubmed/32701074 http://dx.doi.org/10.1093/ckj/sfz166 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Exceptional Cases
Gamayo, Ashley
Hecox, Douglas
Dicker, Lance
Vecchiarelli, Lisa
Raess, Philipp W
Khalighi, Mazdak
Andeen, Nicole K
Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma
title Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma
title_full Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma
title_fullStr Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma
title_full_unstemmed Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma
title_short Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma
title_sort anti-lrp2 nephropathy with concurrent kidney infiltration by lymphoma
topic Exceptional Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367117/
https://www.ncbi.nlm.nih.gov/pubmed/32701074
http://dx.doi.org/10.1093/ckj/sfz166
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