Escherichia coli YcaQ is a DNA glycosylase that unhooks DNA interstrand crosslinks

Interstrand DNA crosslinks (ICLs) are a toxic form of DNA damage that block DNA replication and transcription by tethering the opposing strands of DNA. ICL repair requires unhooking of the tethered strands by either nuclease incision of the DNA backbone or glycosylase cleavage of the crosslinked nuc...

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Detalles Bibliográficos
Autores principales: Bradley, Noah P, Washburn, Lauren A, Christov, Plamen P, Watanabe, Coran M H, Eichman, Brandt F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367128/
https://www.ncbi.nlm.nih.gov/pubmed/32409837
http://dx.doi.org/10.1093/nar/gkaa346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367128/
https://www.ncbi.nlm.nih.gov/pubmed/32409837
http://dx.doi.org/10.1093/nar/gkaa346

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