STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway

Oncosuppressor TP53 and oncogene STAT3 have been shown to engage an interplay in which they negatively influence each other. Conversely, mutant (mut) p53 may sustain STAT3 phosphorylation by displacing SH2 phosphatase while whether STAT3 could influence mutp53 has not been clarified yet. In this stu...

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Detalles Bibliográficos
Autores principales: Romeo, Maria Anele, Gilardini Montani, Maria Saveria, Benedetti, Rossella, Santarelli, Roberta, D'Orazi, Gabriella, Cirone, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367154/
https://www.ncbi.nlm.nih.gov/pubmed/32754441
http://dx.doi.org/10.3389/fonc.2020.01102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367154/
https://www.ncbi.nlm.nih.gov/pubmed/32754441
http://dx.doi.org/10.3389/fonc.2020.01102

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