Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs

2′-5′-Oligoadenylate synthetases (OAS) are innate immune sensors of cytosolic double-stranded RNA (dsRNA) and play a critical role in limiting viral infection. dsRNA binding induces allosteric structural changes in OAS1 that reorganize its catalytic center to promote synthesis of 2′-5′-oligoadenylat...

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Detalles Bibliográficos
Autores principales: Schwartz, Samantha L, Park, Esther N, Vachon, Virginia K, Danzy, Shamika, Lowen, Anice C, Conn, Graeme L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367156/
https://www.ncbi.nlm.nih.gov/pubmed/32678884
http://dx.doi.org/10.1093/nar/gkaa513

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