Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers

Hippo-YAP signaling pathway functions in early lineage differentiation of pluripotent stem cells, but the detailed mechanisms remain elusive. We found that knockout (KO) of Mst1 and Mst2, two key components of the Hippo signaling in mouse embryonic stem cells (ESCs), resulted in a disruption of diff...

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Detalles Bibliográficos
Autores principales: Sun, Xiang, Ren, Zhijun, Cun, Yixian, Zhao, Cai, Huang, Xianglin, Zhou, Jiajian, Hu, Rong, Su, Xiaoxi, Ji, Lu, Li, Peng, Mak, King Lun Kingston, Gao, Feng, Yang, Yi, Xu, He, Ding, Junjun, Cao, Nan, Li, Shuo, Zhang, Wensheng, Lan, Ping, Sun, Hao, Wang, Jinkai, Yuan, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367178/
https://www.ncbi.nlm.nih.gov/pubmed/32510157
http://dx.doi.org/10.1093/nar/gkaa482

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