Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2

The Siah1 and Siah2 ubiquitin ligases are implicated in diverse biological processes ranging from cellular stress responses, signaling to transcriptional regulation. A key substrate of Siah1 is ELL2, which undergoes proteolysis upon polyubiquitination. ELL2 stimulates transcriptional elongation and...

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Detalles Bibliográficos
Autores principales: Wu, Jun, Xue, Yuhua, Gao, Xiang, Zhou, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367184/
https://www.ncbi.nlm.nih.gov/pubmed/32479599
http://dx.doi.org/10.1093/nar/gkaa461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367184/
https://www.ncbi.nlm.nih.gov/pubmed/32479599
http://dx.doi.org/10.1093/nar/gkaa461

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