Disease-associated DNA2 nuclease–helicase protects cells from lethal chromosome under-replication

DNA2 is an essential nuclease–helicase implicated in DNA repair, lagging-strand DNA synthesis, and the recovery of stalled DNA replication forks (RFs). In Saccharomyces cerevisiae, dna2Δ inviability is reversed by deletion of the conserved helicase PIF1 and/or DNA damage checkpoint-mediator RAD9. It...

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Detalles Bibliográficos
Autores principales: Falquet, Benoît, Ölmezer, Gizem, Enkner, Franz, Klein, Dominique, Challa, Kiran, Appanah, Rowin, Gasser, Susan M, Rass, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367196/
https://www.ncbi.nlm.nih.gov/pubmed/32544229
http://dx.doi.org/10.1093/nar/gkaa524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367196/
https://www.ncbi.nlm.nih.gov/pubmed/32544229
http://dx.doi.org/10.1093/nar/gkaa524

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